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2013-7-26 Science
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3 s/ }. K4 a3 c. ^COVER Immunostained fluorescence microscopy image of memory % ~ o. @+ H$ T2 V+ U
engram–bearing cells (red) in the dentate gyrus of a mouse hippocampus (image
* s! a1 E; |; m' M# p( Zwidth: 1.5 millimeters). These cells were genetically tricked to express the
; z$ U- Q$ }0 ^0 h# x+ R7 t7 Gprotein channelrhodopsin-2 during memory formation, thus becoming responsive to
& a0 x0 W9 |9 Y! h3 H9 k2 ?light stimulation. When the cells were activated by light, the mice / p! q8 t7 L4 h
simultaneously associated a genuine memory with an undesirable event (a foot l2 D& ]3 H! C! h2 q
shock) to create a new but false memory. See page 387. Image: 8 g4 F( l0 [1 P* [( H/ s' w- H
Xu Liu and Steve Ramirez ; L u) r h0 Z
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