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2013-7-26 Science3 c% ^% l" o9 X1 p
E/ G1 Y& Y8 I; u b$ u3 ^* w
COVER Immunostained fluorescence microscopy image of memory
1 H. E6 j# k/ @& }6 zengram–bearing cells (red) in the dentate gyrus of a mouse hippocampus (image , A% t- A8 E4 g3 Q3 L
width: 1.5 millimeters). These cells were genetically tricked to express the 4 K( i6 L9 z- w, j
protein channelrhodopsin-2 during memory formation, thus becoming responsive to
5 y2 l$ B8 h- G" g$ _; }* @2 u6 Ulight stimulation. When the cells were activated by light, the mice 2 B8 _% S) n6 r( s2 W9 Z3 X) H
simultaneously associated a genuine memory with an undesirable event (a foot
% h' }% D% z% V$ C8 w) C. hshock) to create a new but false memory. See page 387. Image: 0 E/ ]6 i1 d" ~! F8 x
Xu Liu and Steve Ramirez ) i& S+ D3 d i' d1 z
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