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Cancer Res. 2013 Aug 2. [Epub ahead of print]
/ i$ A0 V; @$ Q# k( `p63, Sharp1, and HIFs: Master Regulators of Metastasis in Triple-Negative Breast Cancer.
; c; W. l. M, B1 U+ o6 u* P' |Piccolo S, Enzo E, Montagner M.
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Authors' Affiliation: Department of Molecular Medicine, School of Medicine, University of Padua, Padua, Italy.3 T$ N/ h& `, F% \' F
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Abstract# D! b* ~# m9 m* p4 w# V2 S! ?
Metastasis is the most significant cause of cancer-associated morbidity and mortality but remains poorly understood. Recent work revealed that metastasis of aggressive triple-negative breast cancers is suppressed by Sharp1, a factor that promotes degradation of hypoxia-inducible factors (HIF) and blunts HIF-induced malignant cell behavior. Cancer Res; 73(16); 1-4. ©2013 AACR.- O2 u; K3 N' l) w- r# V
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PMID: 23913939 [PubMed - as supplied by publisher]
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