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jiays

Science. 1982 Oct 15;218(4569):297-8.3 b1 y- H$ S0 k1 b9 s
An estrogen-binding protein and endogenous ligand in Saccharomyces cerevisiae: possible hormone receptor system.
5 @: M$ r  _0 D" OFeldman D, Do Y, Burshell A, Stathis P, Loose DS.7 g; W" V0 F( h" S
Abstract
3 p+ Y4 k+ b& a0 RA protein macromolecule in the cytosol of the unicellular eukaryotic yeast Saccharomyces cerevisiae selectively binds the vertebrate estrogen hormone 17 beta-estradiol with high affinity. Lipid extracts of the yeast cells or the conditioned growth medium yield a substance that can bind competitively to the tritiated estradiol-binding sites in the yeast and to mammalian estrogen receptors. These findings suggest that the binding protein may be a primitive hormone receptor and that the lipid-extractable substance represents the endogenous ligand.5 O4 p- c# [8 `
PMID: 6289434 [PubMed - indexed for MEDLINE]5 g+ Y3 P8 k6 O! [) w$ J
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网址：http://www.sciencemag.org/content/218/4569/297.long

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