
- 积分
- 13
- 威望
- 13
- 包包
- 49
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Targeted therapies that deliver the expected anti-tumor b0 {# e# H- k: u+ ~
effects while mitigating the adverse effects are taking' W; @' J2 M1 F5 O' q
the cancer world by storm. The need for such therapies
: U$ U' W8 h+ X$ N& z% h6 U# qin non-small cell lung cancer (NSCLC), where systemic
' @6 s/ [% U) ]7 H$ {cytotoxic chemotherapies still remain the backbone of
9 z7 z/ Y1 {' ?, X Fmanagement, is felt more than ever before. Runway
# b$ Q3 D) ]9 O7 Asuccess of immunotherapies such as Ipilimumab for3 q# k) _% E2 a) p) q
melanoma has brought excitement among oncologists.# h2 {; Q& q2 `& {6 m
Immune-based treatments are in various stages of
4 o7 u* I F5 D/ P' jevaluation for NSCLC as well. Immunotherapies using
& M. p! b/ c. ^. Estrategies of antigen based or cell based vaccines, and/ t4 X! |0 }! p
blocking immune checkpoints are of substantial interest.3 a3 C) D, |: {) z0 v& v) G: a
Meaningful clinical responses are yet to be reaped. { ~* X% l7 a2 }
from these new treatment modalities.8 U8 }! F7 Q7 `6 |9 ~& V2 L n
0 L/ N3 J4 O3 f: V% A2 s
/ l+ K5 Q( y2 i/ H5 {
Lung cancer is the leading cause of cancerdeath
9 }. K1 a, \# u8 x) s6 Cworldwide. Majority of these patients have nonsmall
0 }7 O" i8 ^; D4 O! W5 Qcell lung cancer (NSCLC). Traditional chemotherapy: M* V8 V# m5 \( A' P
is limited by its high toxicity. Emerging data have) d$ b8 h( J! Q1 y6 C
demonstrated promising outcome of immunotherapy in
0 k9 B; f. B$ S& F2 aNSCLC. This review delineated the rationale and potential
0 S& [3 |8 t9 g3 x+ j6 w2 Btargets of cancer immunotherapy, with a summary
$ E, d( G: J2 H" b7 Q, [" aof immunotherapeutic agents for treatment of NSCLC.4 }1 S2 y, m; E* Q
Protein/peptide-based and cell-based vaccines, as well
2 o- P: |# c k' D2 ras immune checkpoint targeted agents such as Ipilimumab. Z& Y m% O9 y. z2 @9 ^9 i; w
and PD-1 pathway inhibitors were discussed. In
6 _1 S: l) v- d/ ~. a: L s6 d/ Z) zaddition, we reviewed ongoing immunotherapy-based5 M, {. s7 a# E# t3 m7 p
studies including several major phase Ⅱ/Ⅲ clinical trials,7 k" R+ U: C% t' F& n$ [- J' `
results of which will be available soon for incorporation: V; e8 h8 @2 B" d2 o+ K
into clinical practice. |
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