重磅盘点：2014你不能错过的干细胞论文 TOP 20（揭秘篇）（附原文）

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响应号召，附上 论文清单，请有全文的同道补充。9 M; p% [6 @# J
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Nature：代谢让干细胞永葆青春" X/ \7 O6 R9 ?1 ]" _

2 \; `8 X3 A8 ?7 Y4 r+ Z" k2 TIntracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
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9 \; `. h& m7 K- ^Nature：解密干细胞惊人异质性
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Deconstructing transcriptional heterogeneity in pluripotent stem cells
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+ {5 `" ~4 g* T/ y# UNature：揭开癌症干细胞致耐药之谜6 m0 Z( g3 Y: B; C3 d3 p' a

6 a  \7 N$ a- n; h, kBlocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance
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Cell意外发现：炎症信号造就干细胞
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  a+ g% \  N& A2 M6 Z6 V, x1 xProinflammatory Signaling Regulates Hematopoietic Stem Cell Emergence
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) @2 Q% u# x  U# w0 ~9 k5 jCell Stem Cell：科学家发现体细胞逆转为干细胞的“开关”, A5 b. J" Y7 l; ]6 J: I
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Transcriptional Pause Release Is a Rate-Limiting Step for Somatic Cell Reprogramming8 r, N) o+ ^$ K9 i: |2 o
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PNAS：独特的双功能干细胞# U( k  o+ f8 A9 V% I+ Z# O
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Bifunctional ectodermal stem cells around the nail display dual fate homeostasis and adaptive 0 }* ~% |! c. W8 C& t5 K# f3 B
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wounding response toward nail regeneration% Q9 v0 [- L) g# K- d+ }

8 C" ?" Q- D2 x/ N, k! i' q" D6 O2 T8 XNature重大突破：“类初始态”人类干细胞 可发育成任意细胞类型
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2 ^) n+ w/ |/ J) }0 |6 LPrimate-specific endogenous retrovirus-driven transcription defines naive-like stem cells
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+ J) A$ L' r! x7 k" Z( ePNAS：从骨髓中发现罕见干细胞的新技术$ p: b+ i0 a( M0 V! [& m/ o

# t# g- I, c. NMultivariate biophysical markers predictive of mesenchymal stromal cell multipotency
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0 x* v8 n. E  `- Q) UScience重大突破：首次实现脐带血干细胞增殖
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Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal
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. q. F4 P1 L2 v2 kCell重大突破：多能干细胞变“全能” 可分化任意类型细胞5 [7 n1 i: c* U8 B! l2 g

% D9 m. J1 R0 tResetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human7 Y: d7 a) g+ A
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Science：绘制干细胞命运转换表观遗传动态图
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% K: E3 {. Z: x/ K  mChromatin state dynamics during blood formation. O) \. f, D5 Z3 f& n$ F
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Nature：牙齿，意想不到的干细胞来源
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Glial origin of mesenchymal stem cells in a tooth model system8 Q0 l2 t9 {: ?4 _. e& N  m
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Cancer Cell：白血病干细胞为何难以清除6 U9 t5 B6 `! B
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Leukemia Propagating Cells Rebuild an Evolving Niche in Response to Therapy
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2 ~4 v$ B( F9 t, d* `Cell Stem Cell：禁食可使干细胞再生8 a; c# ~. R& K

' ?: `  w. c+ }# w5 [ProlongedFasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regenerationand ! y: k1 d/ z+ s) l( s
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Reverse Immunosuppression
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0 w5 U. g& S" E: I* d: [Nature：科学家成功实现干细胞靶向基因组编辑
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Targeted genome editing in human repopulating haematopoietic stem cells
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Nature：应激干细胞被发现
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4 W- e2 `% j0 i) A. A) tmTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert8 M' z. E, z+ }! y# S1 L
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Cell：转录因子决定肿瘤干细胞的命运# L- _! O/ z+ n6 t- G
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Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells
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# ^- Y) v, e3 r4 nNature Methods：白血病干细胞体外培养获得重大突破
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Identification of small molecules that support human leukemia stem cell activity ex vivo; ~% {, l6 ~; I& [2 s- z; g$ X

' o/ x( o) I6 P9 U/ ONature：揭示控制干细胞衰老的遗传开关
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6 ~1 y, [4 i; \7 DGeriatric muscle stem cells switch reversible quiescence into senescence
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Nature：揭示长寿的乳腺干细胞1 F9 _8 M- q4 z( j1 Q9 B4 q3 r* P

) E' G9 a! l/ f9 S( I/ ?In situ identification of bipotent stem cells in the mammary gland