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Craig T. Jordan, Ph.D., Monica L. Guzman, Ph.D., and Mark Noble, Ph.D.7 k9 \, g+ I p0 j
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The deepening of our understanding of normal biology has made+ |6 S& H/ H% }% q# z
it clear that stem cells have a critical role not only in the generation of complex+ K9 z e& Z% e9 v! Y
multicellular organisms, but also in the development of tumors. Recent
3 b3 K @/ v: {/ L# {findings support the concept that cells with the properties of stem cells are integral
2 X( J* v1 c8 y7 ]( |/ Q) Yto the development and perpetuation of several forms of human cancer.1-3 Eradication
# y) A- K9 ?; Lof the stem-cell compartment of a tumor also may be essential to achieve stable,# z2 f1 \- K1 B0 p, } H, G$ J- z
long-lasting remission, and even a cure, of cancer.4,5 Advances in our knowledge of" r* s+ f; C2 @
the properties of stem cells have made specific targeting and eradication of cancer% N/ S$ z( y) x @) d1 F) h
stem cells a topic of considerable interest. In this article, we discuss the properties a$ }- b9 R, N+ W, l3 F
of cancer stem cells, outline initial therapeutic strategies against them, and present4 K' y. ^, ^/ K; H. T0 V) E& u
challenges for the future.$ d8 V1 K+ i" F4 W' Y
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