《细胞》[Cell]12年4月27日出版pdf全文

nero1981

4 l7 {( @: G8 V! \' e7 f4 zVolume 149, Issue 3
  \6 }3 H- }% d% b  HOn the cover: The combined activity of neurons in the brain generates , I) d, a0 a( \+ e
oscillatory rhythms, or “brain waves,” that can be detected by
. }# O" G' X  n1 welectroencephalographic recordings. Verret et al. (pp.708–721) found that these : t+ A" e+ [) `  r( w2 M
brain waves, which are represented on the cover by an undulating pattern, are + w' |3 J4 V+ T  L! r
altered in mouse model of Alzheimer's disease (AD), and the changes are linked 6 _2 ~! i' H5 z
to reduced levels of a voltage-gated sodium channel subunit, Nav1.1. Restoring 8 v2 {+ |) f5 {" _1 q2 K
Nav1.1 levels specifically in inhibitory interneurons improves oscillatory
8 r. \8 {& L1 N/ \rhythms and memory in AD mice, offering a new therapeutic approach for , S8 I! U6 W- C" e# m
potentially treating cognitive disorders. The image was created by Arantxa
% K/ Q: X  G: K; s3 Q" n) r6 dEsteban (original paintings “Ondas 1” and “Ondas 2”) and Jorge J. Palop : \2 K) {. n2 _, M- s5 ]) c5 Z
(electronic recreation).* H% w" z/ t8 \3 w2 G
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