ips的克隆不长大是什么原因

lchanlon

回复 mecol 的帖子/ D, P  q9 N* h4 ^/ r

/ t3 G' E; `( OI would say the clone you got is not a fully reprogrammed iPSC. When somatic cells received reprogramming factors, cells were going to be different stages. They might die, apoptosis, transform, senescence et al. It is a very heterogeneous population. Some cells started to reprogram, but they stopped at different stages. Some cells go to a stage to iPSC, then go back to somatic status. Only a very small percentage of cells ultimately become fully iPSC.