PPT:Themes in B cell development (UCSF)

aspen

+ L: @3 ]( B' S5 }5 u' b, n& ]
% i* ]- `' ^2 ~" g4 o/ U: M4 s" t5 S! WAnthony DeFranco
% o* ?, n% J% [1 G1 CDepartment of Microbiology & Immunology, University of California at San Francisco
' l( n# X3 X$ O  r# N9 L' A
, l; p5 H1 c$ P* i) y* m: HThemes include:
) V/ P, E3 G8 E$ F; T9 |. [1. Checkpoints in B cell development:  feedback from Ig gene rearrangements. W( s' C1 D' T& l- Y1 `* O
2. Stromal environment/growth factors for B cell development% l  R. g0 @+ c7 s3 r$ V9 F
3. Lineage commitment:  transcription factors and Notch signaling8 T( x2 O+ K6 W! [/ y. v
4. Central tolerance of B cells
) H+ x6 C0 q; @. {: E4 Y8 q5. Peripheral tolerance of B cells
$ z+ {' x1 h7 x% X8 u. B6 c6. 3 different types of mature B cells: choice of cell fate and relative roles

hualin840518

thanks

hughliang

非常感谢！
, N. \) R7 _/ P; o% v# m; H. L

rainsky1314

thanks very much !

刘子文

谢谢

beidouhan

好东西呢