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李令杰，金 颖* % h+ d+ |1 [3 ^5 _& y% P, o8 _! L
（中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所干细胞重点实验室，上海 200025） 6 B' f0 W( M1 V* t7 h! ?. x' n
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摘 要：胚胎干细胞(embryonic stem cells，ES细胞)具有自我更新和发育多能性的特点，在再生医学研究中有着广泛的应用前景。ES细胞多能性和自我更新的维持受到复杂的调控，涉及到转录调控、信号转导以及表观遗传调控等多个方面。转录因子Oct4、Sox2、Nanog在其中扮演着非常重要的角色，对干细胞特性的维持必不可少。本文着重讨论了这些关键转录因子的研究进展。这些研究促进了对ES细胞自我更新机制的深入理解，并为进一步的临床研究提供了理论基础。
& Q" v9 k0 P O& [7 {( k$ _0 P关键词：胚胎干细胞；自我更新；多能性；关键转录因子；Oct4；Sox2；Nanog
6 p' P. \7 u" M A- }. D+ g中图分类号：Q813 文献标识码：A: D1 I6 q" M+ x
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Research progress on the key transcription factors governing the self-renewal of embryonic stem cells
1 `8 G' ] ~2 u5 ]1 _2 tLI Ling-jie, JIN Ying*
: |; X9 @& a' q(Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China) * z0 I. z* [0 f' L* B( n4 k
. f$ _# r& r/ w. pAbstract: Embryonic stem (ES) cells are pluripotent and capable of self-renewal, thus holding the promise for regenerative medicine. The mechanism underlying pluripotency and self-renewal is governed at multiple levels, involving the transcriptional regulation, signal transduction and epigenetic regulation and so on. Transcription factors Oct4, Sox2 and Nanog play a critical role in this regulatory network and are critical for maintaining ES cell identity. In this review, we discuss the recent advances of these key regulators. These studies will facilitate the understanding of the mechanisms of self-renewal in ES cells and provide theoretical basis on its clinical application.
2 S7 C5 w* G2 TKey words: ES cells; self-renewal; pluripotency; key transcription factors; Oct4; Sox2; Nanog |
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发表于 2009-11-23 10:52
