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本帖最后由 qgjin 于 2010-5-10 00:42 编辑 " C* D: |+ B1 c1 y" A; p5 j E' D" }
4 o0 w+ g# m5 p4 f7 cDerivation of Oocytes from Mouse Embryonic Stem Cells
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& i6 a/ J: X! ]Karin Hu¨bner,1 Guy Fuhrmann,3 Lane K. Christenson,4 James Kehler,1 Rolland Reinbold,1 Rabindranath De La Fuente,2 Jennifer Wood,4 Jerome F. Strauss III,4 Michele Boiani,1 Hans R. Scho¨ler1*& P, U' a! i* ?$ h# o' C6 v+ Z$ B
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, X. D# d1 `0 C& M+ q! ]Continuation of mammalian species requires the formation and development of the sexually dimorphic germ cells. Cultured embryonic stem cells are generally
/ P* q0 N. R% ?" n* a0 lconsidered pluripotent rather than totipotent because of the failure to detect germline cells under differentiating conditions. Here we show that
! i( R v/ C6 v, R8 r; Imouse embryonic stem cells in culture can develop into oogonia that enter meiosis, recruit adjacent cells to form follicle-like structures, and later develop3 {; n' r5 l$ B* V; B# t. @' @
into blastocysts. Oogenesis in culture should contribute to various areas, including nuclear transfer and manipulation of the germ line, and advance studies. e/ z7 e/ v+ L4 [( \! e
on fertility treatment and germ and somatic cell interaction and differentiation. |
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发表于 2010-5-10 00:37
发表于 2010-10-26 09:56
