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本帖最后由 细胞海洋 于 2010-6-19 19:10 编辑
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PREFACE
3 Y1 k. z' Z3 i }5 t/ MThis book has been constructed primarily as a textbook for a one- or two-semester! g1 k/ } V$ y/ j; |
course in statistical bioinformatics. We hope that it will first serve as a comprehensive+ D- \) w1 b$ E+ I) \1 h# t& x; i
introduction to a broad range of topics in this area for life science students and0 a2 Z5 d- g, c2 _/ D& R1 w4 O- ]
researchers who are motivated to learn statistical analysis concepts and techniques
2 R9 j, R$ L9 S% m2 o# d: vin bioinformatics. Statistical and quantitative science audiences who have not yet
2 l' D% ~. G% N2 U5 \' A6 @4 idealt with challenging statistical issues in recent information-rich biological and biomedical
2 P' A! B7 B Z0 }data analysis may also benefit from this book by efficiently reviewing the- w& h2 w& n! Z
different statistical concepts and techniques in such analyses. In particular, the four! n, V7 y8 ^- C4 Y$ D3 e
separate blocks in this book—statistical foundation, high-dimensional analysis,* q* R+ i2 Q' t
advanced topics, and multigene systems analysis—can be somewhat independently3 n- s; E6 A% y# Q# ^' t, }* Y
studied and taught in a course based on relevant needs and time restrictions for an
$ ]8 v! [% |. Y: [: q3 |effective learning purpose.
Y9 |% S& |5 {* vA similar outline as organized in this book has been used for several years in a
0 a6 n3 f* P; G& m" uone-semester graduate course which is open to students with diverse backgrounds at0 L( C* x7 u ^" C! N
the University of Virginia. By publishing this book, we felt that these contents9 }6 q" z& U/ G+ f9 F
could be significantly enhanced by direct contributions of more specialized experts
0 x% [& B. B2 A: \in the broad field of bioinformatics. In this multiauthor book, we have yet tried to, O, H6 N6 N& ^: X, }2 o+ ~' s
maintain the need of a high-level mathematical and statistical understanding at a minimum.% G% G, L: D+ |6 L! T7 g
Readers of this book are thus assumed to have not much more than a basic college. a# C4 C8 }& U# s2 e- `) y
calculus level of mathematical understanding. A knowledge of matrix algebra M) _5 w# o0 }$ N
would also be useful but is not a prerequisite.
4 L+ ]4 y) L/ hThis book is certainly a tribute to the contributions and support of many people.
4 q8 G! x! `+ S1 X! sAcknowledgments are first due to the succeeding life science editors of JohnWiley &
" q+ K: @" l* w( c! bSons: Luna Han, Thomas Moore, and Karen Chambers.Without their continuous support
7 G/ h* Z7 T7 Y/ Aand encouragement, the publication of this book would not have been possible.2 o ]" R& q8 K% Q* D
Also, all the efforts made by the expert authors who were willing to participate in% ]) {! U4 i2 r. X6 y/ Y u% E. g
this book should be highly acknowledged for its successful completion. Finally, the
L( R v6 f3 i& o5 Lstudents who have taken this initial course and provided valuable feedback on various
& L% `2 d( q( H0 W4 ztopics in this area over the last several years are also significant contributors to the
$ S4 H2 Z7 ?1 j' d7 Z0 m% pcurrent form of the book. The preparation of this book was supported in part by the6 f4 C; h/ {. V0 F8 Z! O2 A, H
National Institutes of Health Research Grant R01 HL081690.5 S+ {- I2 L) l$ r. L( F E% ~* w
J. K. LEE0 u* F- h1 J2 m$ \, ?) ~' A
Division of Biostatistics and Epidemiology4 O" |0 w* _2 l, }5 {
Charlottesville, Virginia- q$ ^3 f( h7 c! k* z: v
xi
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发表于 2010-6-19 15:22
发表于 2010-6-20 10:57
