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关于iPS的作用机制,这篇Nature Review Molecular Cell Biology的 Review是个不错的归纳:Open chromatin in pluripotency and reprogramming。作者提出了2个原则: specific factors maintain a globally
0 ]' |- o7 [/ O& l) b- o* @open chromatin state that is accessible for transcriptional activation; and other chromatin
( {, H2 e0 h1 T; s2 Z' x- @regulators contribute locally to the silencing of lineage-specific genes until differentiation is
% s9 x: @' a0 E( n* k: I5 C" Xtriggered. |
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