关于iPS的作用机制,这篇Nature Review Molecular Cell Biology的 Review是个不错的归纳:Open chromatin in pluripotency and reprogramming。作者提出了2个原则: specific factors maintain a globally* f% ]9 d4 u& u- [+ F
open chromatin state that is accessible for transcriptional activation; and other chromatin. K1 v4 A7 s( K0 E7 Y
regulators contribute locally to the silencing of lineage-specific genes until differentiation is " f6 W3 l7 P# [5 atriggered.