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关于iPS的作用机制,这篇Nature Review Molecular Cell Biology的 Review是个不错的归纳:Open chromatin in pluripotency and reprogramming。作者提出了2个原则: specific factors maintain a globally
, x8 D4 I2 E( Jopen chromatin state that is accessible for transcriptional activation; and other chromatin, r8 ?- F3 c8 B2 O. N1 K" N* }
regulators contribute locally to the silencing of lineage-specific genes until differentiation is9 z( c# d0 v8 L4 }' a( y
triggered. |
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