关于iPS的作用机制,这篇Nature Review Molecular Cell Biology的 Review是个不错的归纳:Open chromatin in pluripotency and reprogramming。作者提出了2个原则: specific factors maintain a globally/ a5 @" c9 d; f- g* t
open chromatin state that is accessible for transcriptional activation; and other chromatin 3 [+ V) q! Y8 Hregulators contribute locally to the silencing of lineage-specific genes until differentiation is6 r$ ~6 x/ Z. @) F F& b' Z2 n( C6 x
triggered.