科学家发现干细胞活力因子blebbistatin（附原文）

lixiaodong

Thanks a lot.

flankerf

thanks!

215307222

很好的文章，谁能把题目翻译一下，要是摘要也翻译就更好了。  & R( ~# p' A( w$ j7 r) p
Non-muscle myosin II regulates survival threshold  of pluripotent stem cells
6 r0 Y# r4 A- k* _8 Z$ t Human pluripotent stem (hPS) cells such as human embryonic stem (hES) and induced
  \4 N' f8 f' z2 Ypluripotent stem (hiPS) cells are vulnerable under single cell conditions, which hampers 2 a' a/ @6 G. a, H; K' A
practical applications; yet, the mechanisms underlying this cell death remain elusive. In this ; I6 p% T& A3 o  {
paper, we demonstrate that treatment with a specifi  c inhibitor of non-muscle myosin II (NMII), ) K/ f& ]6 U4 |* P7 ]6 K, r( R
blebbistatin, enhances the survival of hPS cells under clonal density and suspension conditions,
( O1 t  `9 g% h9 q& ~" |and, in combination with a synthetic matrix, supports a fully defi  ned environment for self-2 h# O7 T2 p; p& t1 B
renewal. Consistent with this, genetically engineered mouse embryonic stem cells lacking an 9 u6 B' w! K1 z0 @/ j! e  T
isoform of NMII heavy chain (NMHCII), or hES cells expressing a short hairpin RNA to knock
! z$ ^( T8 K, j( kdown NMHCII, show greater viability than controls. Moreover, NMII inhibition increases the
. x& I* g" \. [2 N% A0 a/ @expression of self-renewal regulators Oct3 / 4 and Nanog, suggesting a mechanistic connection
' M6 u# g/ R, w) I- S. K3 j- Ibetween NMII and self-renewal. These results underscore the importance of the molecular
$ v& [' u  d8 o$ T  s. ]motor, NMII, as a novel target for chemically engineering the survival and self-renewal of
! @9 ]1 U7 ]  j# Z8 ahPS cells.

fjmedzengyue

谢谢

aidiulgy9517

非常感谢原文提供

dwl1209

学习了