多能间质细胞治疗与肾脏疾病和肾移植

decloud2009

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Multipotent mesenchymal stromal cell therapy in renal disease and kidney transplantation
5 s: j% y  w; [, l  V# xMarlies E.J. Reinders1, Willem E. Fibbe3 and Ton J. Rabelink1,2 8 c! }0 u7 H; L/ k! U
Nephrol. Dial. Transplant. (2010) 25 (1): 17-24. doi: 10.1093/ndt/gfp552。
" k' J' S9 P6 H' w8 nAbstract：Cell therapies aim at differentiation of stem cells into the specific cell type required to repair damaged or destroyed cells or tissues. Over recent years, cell therapy has been introduced in a variety of application areas, including cardiovascular repair, diabetes, musculoskeletal disorders and renal repair. Multipotent mesenchymal stromal cells (MSCs), often referred to as mesenchymal stem cells, are of particular interest as a cell therapy model, as this is one of the few cell types that are on the brink of entering the clinical arena in different areas of application. MSCs can be differentiated in vitro and in vivo into various cell types of mesenchymal origin such as bone, fat and cartilage. They have important effects on the innate and adaptive immune system and possess striking anti-inflammatory properties that make them attractive for potential use in diseases characterized by autoimmunity and inflammation. In addition, MSCs have been shown to migrate to sites of tissue injury and to enhance repair by secreting anti-fibrotic and pro-angiogenic factors. In this review, evidence for the renoprotective mechanisms of MSCs as well as their therapeutic possibilities and potential hazards in acute and chronic renal disease and allograft rejection is summarized5 T% m9 K2 l) J; P1 I( l. j
标题：多能间质细胞治疗与肾脏疾病和肾移植
+ N/ q+ V9 D$ f! o摘要： 细胞治疗是把干细胞分化成特殊细胞类型来治疗受损细胞或者组织的方法. 近年来,细胞治疗涉及了各个应用领域,包括心血管修复,糖尿病,骨骼肌疾病,肾脏疾病. 多能间质细胞(MSCs),一般被认为是间质干细胞, 是极少数的有可能进入临床领域并具有多方面应用的细胞类型之一,使得其在细胞治疗模型方面得到特别关注. MSCs可以在体内和体外分化成包括间质来源的骨骼, 脂肪和软骨组织等的多种细胞类型. 由于它们与生俱来的免疫系统的适应性和显著的抗炎症的特性,使他们有应用于治疗自身免疫疾病和炎症的潜能.此外,MSCs可以转移到组织受损的部位,并通过分泌抗纤维变性因子和促血管生成因子来帮助组织修复. 在这篇综述,概括了MSCs在急慢性肾脏疾病和同位异体移植排斥反应中保护肾脏的机制,及治疗的可能性和潜在危险..
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文献来源：http://ndt.oxfordjournals.org/content/25/1/17.abstract$ h9 j9 @' W# y' ~, T
难点：就是题目啊，一看地球人都知道这个意思，就是不知道怎么翻译好。
4 E* w; ]/ z* g# {' c说明：原文来源自xxx 由干细胞之家新闻小组成员decloud2009翻译（转帖请注明）。个人翻译，理解不准确的语句还望大家积极指出。" P3 ~+ ~4 C  `- n3 ^2 A

decloud2009

3：33，困死我了。。睡觉去。话说，，大家给力一点啦，看贴回回好不好，会打击积极性的呀。
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我都很乖的，看贴必回。。

deron

Multipotent mesenchymal stromal cell therapy in renal disease and kidney transplantation6 w; N' T. b8 S5 k3 ]
标题是否应强调“多能间充质细胞在肾病和肾移植中的治疗应用”？楼主的译法通俗易懂，旨在与强调前者与后者内在的联系——但也有两者并列的歧义。第一次看的时候就理解错了。
$ \! U& Z4 a, |5 S9 V/ N& C4 K7 ^“分泌抗纤维变性引资”，引资是打字的失误，应该为“因子”，这个，请海洋帮忙改吧~$ i( O* o1 m1 Y, d
楼主熬夜翻译的精神……可要注重自己的身体呵

lhj8100

楼子幸苦了

mbjane

辛苦，谢谢楼主

johnson

请问楼主，能治疗尿毒症吗

细胞海洋

回复 deron 的帖子
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修改了
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chb611301

支持

stemcell313

thanks

decloud2009

我还是继续发这里吧,,5 z- Q7 e% g6 I9 |0 ^
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全文内容部分翻译..实在翻不下去了,,并且个人决定这篇文章还是很浅显易懂的,因此上,大家还是去看原文吧,,,自己的理解才是自己的东西......