Stem cells found to home toward the injured liver

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日期: 2003-07-16 今日/总浏览: 1/578
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- j: Y7 G0 V; }4 q) rThenowrecognizedplasticityofstemcellschallengesresearcherstofurtherdefinethemechanismsresponsiblefortheirrecruitmentanddifferentiation,sothattheymayultimatelybecomeclinicallyusefulintherepairofinjuredorgans.
0 J: V) B* @4 X' ~6 R" t. x% iIntheJuly15issueofTheJournalofClinicalInvestigation,acollaborativeresearchteamledbyTsveeLapidotandcolleaguesattheWeizmannInstituteofScienceinIsrael,andalsoincludingresearchersfromtheAlbertEinsteinCollegeofMedicineandMountSinaiMedicalCenterinNewYork,InstitutPasteurinParis,andtheChaimShebaMedicalCenter,Israel,havereportedastudythatgreatlycontributestoourunderstandingofhowhematopoieticstemcells(HSCs)hometoinjuredlivertissueandcontributetotissuerepair.TheauthorsrevealthatmigrationofHSCstotheliverisaselective,non-randomevent,requiringtheexpressionofthesignalingchemokineSDF-1andthereceptorCXCR4.ThepathwaysthatfacilitatecrosstalkbetweenHSCsandinjuredlivertissuemayserveastargetsforfuturetherapeuticprotocolsinthefieldofliverregenerationandtransplantation.! K7 p6 v. S: W, R  ]5 I
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- d  F8 u% N- T+ k! a6 M4 l4 UTITLE:HGF,SDF-1,andMMP-9areinvolvedinstress-inducedhumanCD34 stemcellrecruitmenttotheliver* t& ~  U8 B3 w9 S$ j; |
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AUTHORCONTACT:) F0 ^/ X8 y; t, Z; U8 Y1 ?6 `
TsveeLapidot: d" w% k# \3 k. w$ Z0 v3 o
TheWeizmannInstituteofScience,Rehovot,Israel.
" G5 m/ E- L% T( E4 R. u7 j% a% @Phone:972-8-934-2481+ O1 {( J7 z5 Z1 a" {. f
Fax:972-8-934-4141
4 q* A0 Q# J" Y3 c+ kEmail:Tsvee.Lapidot@weizmann.ac.il; S* P5 G) [4 C$ C6 [9 `2 |

" e( N# Q. m6 s* m0 {" G/ U& FViewthePDFofthisarticleat:https://www.the-jci.org/press/17902.pdf
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* K; {' K& G- S2 c作者: * E0 b% B, Q7 u1 w  m. V( t
来源: Journal of Clinical Investigation
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