猴子ips，对于临床应用的意义，大家来讨论一下吧。

bathpp2007

Reprogramming Huntington monkey skin cells into pluripotent stem cells.4 D4 O- ^& _  U; A. g4 _
Chan AW, Cheng PH, Neumann A, Yang JJ.
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# s& m7 i' O; W( W$ HYerkes National Primate Research Center, Emory University School of Medicine, Atlanta, Georgia 30329, USA. awchan@emory.edu* B" q0 G& u1 `! s
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Abstract
5 ]; ]/ i4 t" _5 x( u0 y3 ~: CInduced pluripotent Huntington's disease monkey stem cells (rHD-iPSCs) were established by the overexpression of rhesus macaque transcription factors (Oct4, Sox2, and Klf4) in transgenic Huntington's monkey skin fibroblasts. The rHD-iPSCs were pluripotent and capable of differentiating into neuronal cell types in vitro and developed teratoma in immune compromised mice. We also demonstrated the upregulation of endogenous Oct4 and Sox2 after successful reprogramming to pluripotency in rHD-iPSCs, which was not expressed in skin fibroblasts. rHD-iPSCs also developed cellular features comparable to Huntington's disease (HD), including the accumulation of mutant huntingtin (htt) aggregate and the formation of intranuclear inclusions (NIs) paralleling neural differentiation in vitro. Induced pluripotent stem cells from transgenic HD monkeys open a new era of nonhuman primate modeling of human diseases. rHD-iPSCs that develop key HD cellular features and parallel neural differentiation can be a powerful platform for investigating the developmental impact on HD pathogenesis and developing new therapies, which can be evaluated in HD monkeys from whom the rHD-iPSCs were derived.9 ~" B& G, R% D1 c1 ~5 Z

% W. L7 z2 m' H7 `PMID: 20936902 [PubMed - indexed for MEDLINE]PMCID: PMC2993046 [Available on 2011/10/1]
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bathpp2007

原文

have-a-rest

就不知这种来源的ips是否可以治疗亨廷顿，如果能，为什么？如果能，可否借鉴ips的思路治疗这一疾病。

guosapphire

我认识这些细胞目前最主要的用途是用于研究huntington的病理机制或作为治疗靶点赛选的平台。

holly_g_v

Huntington's disease 非人类灵长类模型的建立一定可以通过病理药理实验研究出缓建或是治疗Huntington's disease的好药物或是方法。我们期待着~