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J Craniofac Surg. 2011 Mar 9. [Epub ahead of print] 8 b, D! i: P0 y, _
Mandibular Alveolar Bony Defect Repair Using Bone Morphogenetic Protein 2-Expressing Autologous Mesenchymal Stem Cells.+ N1 B; y% h8 _: l0 I/ v8 I
Chung VH, Chen AY, Kwan CC, Chen PK, Chang SC.
3 d! T9 [" w1 {( UFrom the *Department of Applied Chemistry, Providence University, Taichung, †Department of Dentistry, Chang-Gung Memorial Hospital, Taoyuan; ‡Department of Plastic Surgery, Chang Gung Memorial Hospital, Chang Gung University College of Medicine; Taoyuan; and §Department of Plastic Surgery and ∥School of Medicine, China Medical University, Taichung,Taiwan.1 m. a$ M8 H* Z2 n2 U4 ? R
Abstract' P" G; i' _9 y
BACKGROUND: Mandibular bone regeneration is stepped up by human recombinant bone morphogenetic protein 2 (BMP-2) whose application is also related to limited cementum and periodontal ligament regeneration, local root resorption, and ankylosis. The alveolar bone grafting without traditional autologous bone grafts remains a challenge for plastic surgeons.. E& R7 x9 w1 B* r
METHODS: Bilateral mandibular alveolar and periodontal defects were created over the premolar areas in 9 mature male beagles. The defects were randomly assigned for either the adenovirus BMP-2 (advBMP-2) group with BMP-2-expressing mesenchymal stem cells (MSCs) or the control with MSCs alone. The regenerated periodontal attachment apparatus was evaluated histologically, and the whole regenerated bone volume was scrutinized from three-dimensional computed tomography analysis.5 y- k, F2 a% B- Y
RESULTS: Periodontal apparatus regeneration was significantly better in the advBMP-2 group. New cementum and Sharpey fibers were observed on the denuded root surfaces in the advBMP-2 group, whereas incomplete healing with localized root surface resorption was noted in the control group. Eight weeks after implantation, the advBMP-2 group showed significant increase in bone regeneration than the control one.: \9 F" V( A @0 i0 Y% ^& r
CONCLUSIONS: Thus, the use of ex vivo BMP-2-engineered autologous MSCs boosted bone and periodontal apparatus regeneration in mandibular periodontal defects. This de novo approach might be suitable for clinical mandibular bone repair and periodontal apparatus repair.6 `1 a- a# s" l Z, c: d7 P
PMID: 21403565 [PubMed - as supplied by publisher]4 ^# H( C4 K! \) g
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发表于 2011-4-2 22:03
，我一下转不过弯来，呵呵，正在改进中…… O X/ s! M ^, @8 L* I