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Correspondence regarding this Primer should be sent to Marshall A. Lichtman, M.D., 601 Elmwood Avenue, Box 610, Rochester, NY 14642 or mal@urmc.rochester.edu. j6 ]5 ]1 a9 h% Y4 l6 x
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Stromal cells elaborate.7 n, F+ Q9 m2 I {$ x6 g: S
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Cytokines orchestrate.0 n T4 N' z7 ^6 m0 A8 l! ^
, I0 X4 N) z: ~* r0 b( OSignal transducers propagate.
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Genes dictate.# J1 M* f B g
' [+ l. a# v* Y. jTranscription factors mediate. mRNAs translate.) r( ~! u$ G# d5 c8 ^
( I$ L# ^ g, ]9 \1 k8 I) HProteins effectuate
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! o& T1 s2 R( M3 g6 c/ SStem cells differentiate.
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(It appears that they can also transmutate!)# |8 e: k7 W% {
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Progenitor cells proliferate$ J# R! f+ q4 {: Q. B# T0 |: ?
" Q% T m/ Y: w. m1 L' BErythroblasts hemoglobinate
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Myelocytes granulate.
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Megakaryocytes fragmentate.: y8 z6 n: F0 J: e( t
7 A J3 e& z/ a# w4 [; [ a, ^* d5 QMature cells circulate.- ^# x2 T6 s3 b& }, f' v
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Blood cell counts fluctuate.
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3 ~* g0 z: ~* e6 y$ JRed cells oxygenate.6 p! V; Q# W# Z0 |8 w8 J) b, V1 T4 ~* P
% z9 _( K* o6 n, U* |9 tNeutrophils emigrate.
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8 j V1 h' X. R' tBasophils and eosinophils degranulate.4 @, `. v" C$ x/ J( M
/ A R8 B7 C' i* lMonocytes transfigurate.5 ~' P) v! _0 s% t
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Dendritic cells cooperate.
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' z) v6 }) l7 ?+ m9 d: W& YLymphocytes activate.
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End cells disintegrate.6 U4 q2 C+ z+ |; h/ C5 y7 o
/ ^2 K# `2 ]6 m Y; K$ t+ ]
Hematopoietic scientists cogitate,
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6 }" M" z# ?7 a/ y ]6 ?' \& {6 E; o! oThen, they may elutriate.
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Hematologists medicate, A' D+ H; @6 q4 M$ V# Q: E
8 V% S. r/ a( i; D1 gAnd occasionally they irradiate.$ G% y% |* d# }" v
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Followed sometimes by a stem cell infusate.
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They also may prognosticate,' l! r6 \ c; l3 J6 T
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But they often over- or under-estimate.+ m# O0 c( B4 q
$ x& M- {, P& `+ A9 |/ VNow we have embryonal stem cells on our plate.( r8 a$ j, b, V; M+ o' `; C( l/ x
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Their use is undergoing ethical debate.
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5 \3 P" B8 G* j4 wThe point is that if one can direct their fate,; p2 ?; a h1 p0 C' ]% H Z
5 J$ I _+ g: q2 ZCertain diseases we could abrogate.1 a3 {. A! x3 f s2 s& U. b
4 B, h- t- z% j: q2 J: g2 j' pFOOTNOTES e5 M8 P5 j9 g s$ o
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1 It was initially thought that the author is a distant relative of Paul Ehrlich, the German chemist, immunologist, and Nobel Prize laureate whose research with aniline dyes lead to the polychrome stains for blood and marrow cells and of Alexander A. Maximow, the eminent Russian embryologist and histologist, who provided the first evidence for an hematopoietic stem cell as the source of blood cells. The latter disclosure was made in a lecture delivered to the Hematologic Society of Berlin in 1909. Careful editorial inquiry uncovered that Ehrlich Maximow is the pseudonym of Marshall A. Lichtman, M.D., Professor of Medicine and Biochemistry and Biophysics at the University of Rochester Medical Center.(Ehrlich Maximow1) |
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发表于 2009-3-5 10:36
发表于 2015-6-10 11:35
