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Correspondence regarding this Primer should be sent to Marshall A. Lichtman, M.D., 601 Elmwood Avenue, Box 610, Rochester, NY 14642 or mal@urmc.rochester.edu
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Stromal cells elaborate.
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Cytokines orchestrate.6 K- m [6 i; z* U* l, Z
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Signal transducers propagate.
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Genes dictate.
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# \ o) [9 t* b! E3 o( }Transcription factors mediate. mRNAs translate.
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0 d5 Z, m: ]) E& `+ VProteins effectuate
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Stem cells differentiate.$ M g6 h# c1 u) K1 E: R7 I% J
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(It appears that they can also transmutate!)2 t! x9 y/ D/ S( P2 s7 s, H
5 |5 R; i+ o4 s. w9 v0 lProgenitor cells proliferate; i4 X' T1 z3 ]; W) e, l- t
) z# C: h$ {! \9 w' @1 @Erythroblasts hemoglobinate8 a9 n" `+ m# s- E- a8 t+ p
) C0 i4 W1 U" `. r$ {( g2 [Myelocytes granulate.# y6 L/ q- n6 f# O; M
k# F6 `* l7 g6 fMegakaryocytes fragmentate.
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4 H( D& ]* _- ~. FMature cells circulate.
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Blood cell counts fluctuate.# ^1 f7 V" F; h' h7 e
! N8 Y. x3 M* C$ SRed cells oxygenate./ e. m8 P& f! C6 R) Y1 ?( \0 T
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Neutrophils emigrate.
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7 C" T! B2 ^4 L/ z0 eBasophils and eosinophils degranulate.
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Monocytes transfigurate.9 ]% o( y6 M5 r3 p6 v- t3 V( \
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Dendritic cells cooperate.
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Lymphocytes activate.
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End cells disintegrate.; ?! V( n* A$ ]$ `: I9 }1 B
8 y: P$ m/ q! }Hematopoietic scientists cogitate,5 y$ P! s+ _, `0 d* o
+ i' e' \0 U0 a2 o! FThen, they may elutriate., \% a7 h0 |% b+ T- x
6 @- t m% u ZHematologists medicate,
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And occasionally they irradiate.0 a" J3 l# i, g1 K5 {
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Followed sometimes by a stem cell infusate.
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They also may prognosticate,8 E8 | f, u& y( L. ]$ O. ?8 `
7 ?& C& B M0 j' d! `But they often over- or under-estimate.4 O7 Q, [3 L3 W5 z% {
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Now we have embryonal stem cells on our plate.
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Their use is undergoing ethical debate.; S8 u# a7 c. U& R7 y: T
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The point is that if one can direct their fate,( B. S) m) O" J4 J* \
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Certain diseases we could abrogate.
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7 Q6 R+ {$ H; zFOOTNOTES( y9 e) p! l! h! ?+ y4 {# v
4 @- H0 o! L% U1 e9 I% w4 E1 x! h1 It was initially thought that the author is a distant relative of Paul Ehrlich, the German chemist, immunologist, and Nobel Prize laureate whose research with aniline dyes lead to the polychrome stains for blood and marrow cells and of Alexander A. Maximow, the eminent Russian embryologist and histologist, who provided the first evidence for an hematopoietic stem cell as the source of blood cells. The latter disclosure was made in a lecture delivered to the Hematologic Society of Berlin in 1909. Careful editorial inquiry uncovered that Ehrlich Maximow is the pseudonym of Marshall A. Lichtman, M.D., Professor of Medicine and Biochemistry and Biophysics at the University of Rochester Medical Center.(Ehrlich Maximow1) |
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发表于 2009-3-5 10:36
发表于 2015-6-10 11:35
