【PubMed综述】抑制性肿瘤微环境：肿瘤免疫治疗的挑战

sunsong7

Mol Pharm. 2011 May 5. [Epub ahead of print]
) ^1 @* a0 r: gThe Suppressive Tumor Microenvironment: A Challenge in Cancer Immunotherapy. ) f* F& M2 s4 z. G
Vasievich EA, Huang L.  $ P+ x& @/ n8 i
SourceDivision of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
  {  h( R/ E. ?7 X# ~" [: J4 i! A3 [- N7 F
Abstract, C4 @# ^8 I9 J4 e. n! d
In this review, we introduce the changing public perception of vaccines and immunotherapy in cancer treatments. We discuss the roles that different immunosuppressive cells play in the tumor microenvironment. Tumor associated macrophages (TAMs) and M1 and M2 macrophage phenotypes are discussed in depth. Additionally, the role that myeloid derived suppressor cells (MDSC) and T regulatory cells (Tregs) play in the tumor microenvironment is addressed. Highlighted are examples of therapies used against each suppressive cell type, which vary from the hypothetical to the ineffective; the inefficient to the successful. A variety of treatments have been tried to combat this fundamental problem, indeed the cause that allows cancerous mutated cells to survive, multiply and overtake the body. Efficient methods to disable each particular suppressive type of cell have been introduced; this review summarizes the discussion with a table to guide future development. We see gene therapy as the most innovative and flexible method to lead the charge to specifically modifying the tumor microenvironment.' p/ X! h. X& ^/ M+ T/ S8 p

( T$ o- G) t) W# x, j4 Qhttp://www.ncbi.nlm.nih.gov/pubmed/21545153

我是丁香

谢谢分享

cell1314

有没有全文，分享一下。

我是丁香

附上原文！

Sakya

个人认为，肿瘤的出现跟免疫系统几乎没有任何关系。一个证据就是免疫缺陷性疾病并发的肿瘤很少。

realinter

回复 Sakya 的帖子- ]. ]% i! R5 }3 `. A

5 A8 j/ Q; w+ l那为什么用裸鼠来打畸胎瘤和做肿瘤模型呢

Sakya

这是不同个体之间的移植模型，我的意思是，自身的免疫系统对自体肿瘤没什么攻击作用。

canjian308

现在很多肿瘤免疫治疗，自体免疫细胞体外扩增后，会输体内之，不是都通过化疗清除免疫系统，具体的机理就是清除掉相关的抑制性免疫细胞，这样的效果会更好吗？