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本帖最后由 huangcong1988 于 2011-5-17 09:00 编辑
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This report demonstrates that introduction of microRNAs
) @ `5 x: T/ _4 J3 e) O(miRNAs) specific to embryonic stem cells enhances the0 \5 H- l0 F: E
production of mouse induced pluripotent stem (iPS) cells.! M& p9 A! r) u8 R3 ?
The miRNAs miR-291-3p, miR-294 and miR-295 increase
3 T/ Q% Q' N/ K( k' j$ b% Sthe efficiency of reprogramming by Oct4, Sox2 and Klf4, but
4 C- F* o, S8 r, O7 K9 anot by these factors plus cMyc. cMyc binds the promoter of the
6 z) t# P1 u5 B7 tmiRNAs, suggesting that they are downstream effectors of cMyc6 u, X1 o/ q3 C
during reprogramming. However, unlike cMyc, the miRNAs+ A( D; [4 B3 ?. C' }5 B' |
induce a homogeneous population of iPS cell colonies. |
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发表于 2011-5-17 08:59
发表于 2011-5-17 10:07
