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本帖最后由 FreeCell 于 2011-5-22 02:15 编辑 2 m p) B! N3 z) A! ]9 q
- y- C% M7 m5 R0 n9 @+ k. f9 AStem Cells Reverse Disease in a Model of Parkinson’s Disease t f2 {- l N& g% G
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Researchers from the United States and Korea have used cells derived from different types of human stem cell to reverse Parkinson’s disease in a rat model. They announced in The Journal of Clinical Investigation that they have identified a stem cell population that they believe could be clinically relevant for new human trials.* Y0 p% V# J. r) i0 Z
7 X3 i% m* a- W! i+ O3 J/ FParkinson’s disease is one of the most common nervous system disorders of the elderly, affecting nearly one million people in the United States alone. Most often it affects people above the age of 50, but younger people, especially those with family histories of the disease. Parkinson’s disease occurs when the nerve cells in the brain that make dopamine are slowly destroyed. Dopamine is used by nerve cells in the brain to help control muscle movement. Without dopamine, the nerve cells in that part of the brain cannot properly send messages. This leads to the loss of muscle function, and the damage gets progressively worse with time. Parkinson’s disease is incurable; the most patients can hope for now is to manage the symptoms with medication. Unfortunately, some of the side effects of common medications are severe: nausea, diarrhea, hallucinations, and delirium. 8 Y: s7 }. f6 V" ~% u- D2 n; f
: m- x3 e r' mParkinson’s disease is a good candidate for stem cell therapies because it is caused by the death of one particular type of cell. Many advocates, including celebrities such as Michael J. Fox, who suffers from Parkinson’s and has endowed a research foundation, have focused on using embryonic stem cells as a way to treat the disease. Because of the controversy about the use of embryonic stem cells, other scientists have turned to adult stem cells." n1 R2 ^( @/ @6 }. G/ F- t
% U2 U8 ~# M' a# P) k6 E4 TIn the recent study, doctors Sang-Hun Lee from Hanyang University’s medical school (Korea) and Kwang-Soo Kim from McLean Hospital and Harvard University (Boston) used induced pluripotent stem cells (iPS cells)—adult cells that have been reprogrammed back to a state from which they can develop into other human cells. Human cells can be reprogrammed to become iPS cells in one of two ways: cells can be injected directly with reprogramming proteins (protein-based iPS cells) or viruses can be used to deliver to the cells the genetic information necessary for producing the reprogramming proteins (virus-based iPS cell).
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Scientists in this study found several problems with cells derived from virus-based human iPS cells that precluded their use in the Parkinson’s disease model but found that nerve cells derived from protein-based human iPS cells reversed disease when transplanted into the brain of rats modeling Parkinson’s disease. They therefore conclude that protein-based human iPS cells could be used in the treatment of individuals with Parkinson’s disease and project: “Our results suggest that protein-based reprogramming may be a viable approach for generating a patient-specific source of cells for treatment of [Parkinson's disease] and other degenerative diseases.”) A1 y* E9 @ Q0 V7 X; E
http://www.medicineforanewera.co ... parkinsons-disease// \* S& a/ \2 g& `) a4 i
Read the research report at The Journal of Clinical Investigation.
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发表于 2011-5-22 02:10
发表于 2011-5-22 09:51
