Stem Cell Aging—NCB review2011

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Emerging models and paradigms for stem cell ageing0 D! o* K, v( u$ [& o
D. Leanne Jones and Thomas A. Rando4 [* @/ J' }/ [# ?$ t
Ageing is accompanied by a progressive decline in stem cell function, resulting in less effective tissue homeostasis and repair. Here we discuss emerging invertebrate models that provide insights into molecular pathways of age-related stem cell dysfunction in mammals, and we present various paradigms of how stem cell functionality changes with age, including impaired self-renewal and aberrant differentiation potential.

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