SnapShot: Hair Follicle Stem Cells

zorro

+ W. l. o% W: |% l9 S$ d) i& W3 U
7 z+ p5 G2 k" o3 h7 T* ^. M/ E
6 `( E) W/ `' ?! V5 ?3 g) I
Browse stem cell articles via key phrases:
$ e$ @' M% N4 w- MRelated Articles:( W6 K$ }7 [( r# {$ H* m/ s
Pluripotency of mesenchymal stem cells derived from adult marrow.$ Q7 T0 D( t1 N  S1 g6 O% H! h/ y
Nature Jul 04, 20028 L1 g- z+ ~  x% ?! X. y) C
We report here that cells co-purifying with mesenchymal stem cells--termed here multipotent adult progenitor cells or MAPCs--differentiate, at the single cell level, not only into mesenchymal cells, but also cells with visceral mesoderm, neuroectoderm and ... 9 j" T7 T* A. t% q& j& P) x8 Y

  t4 }: t) @" b: t6 Q2 a5 H3 H- \! [- f5 G' R
Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion.
) L/ V; v0 x7 ZNature Apr 04, 2002
- Z+ A1 U3 V$ h% G; u0 cRecent studies have demonstrated that transplanted bone marrow cells can turn into unexpected lineages including myocytes, hepatocytes, neurons and many others. A potential problem, however, is that reports discussing such 'transdifferentiation' in vivo ...
% O. y3 B: Z1 ?1 Z# ]& u" H) A
) P; F* B# \/ v7 x; c* n  N6 n( l2 M6 U) M, N" ]/ o
Cell fusion is the principal source of bone-marrow-derived hepatocytes.+ x4 l/ v- i$ w4 d7 a, P  Z
Nature Apr 24, 2003
  N  k5 T7 d9 ?% @1 L' s. U, {, hEvidence suggests that haematopoietic stem cells might have unexpected developmental plasticity, highlighting therapeutic potential. For example, bone-marrow-derived hepatocytes can repopulate the liver of mice with fumarylacetoacetate hydrolase ... ( z/ b+ I+ [+ r' [; q
# v0 O3 _7 ?. h2 y4 h, l# F

# b) s; u7 ]' k$ g/ \Multilineage potential of adult human mesenchymal stem cells.
) r& m: _+ l0 F- g- b: r, v! f1 WScience Apr 22, 1999
5 H) n. d0 I& u' U; v' s3 m7 xHuman mesenchymal stem cells are thought to be multipotent cells, which are present in adult marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including bone, cartilage, ...
/ _( j% F0 C' v& @; r5 }3 `
$ y/ p, a  ?2 ^: H1 j. b3 t
: _2 T) \' Z6 G5 D5 [Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell.4 t- k/ l. ?' r/ ^! |
Cell May 11, 2001  I" p4 c/ H( n% U- U6 N0 o
Purification of rare hematopoietic stem cell(s) (HSC) to homogeneity is required to study their self-renewal, differentiation, phenotype, and homing. Long-term repopulation (LTR) of irradiated hosts and serial transplantation to secondary hosts represent ...
' Z$ ^$ r% \+ G9 R; u3 k" `! E- j( e  h0 x' p

3 U5 }* `6 D% x' K/ j2 T"Stemness": transcriptional profiling of embryonic and adult stem cells.
/ T; C4 W! U9 f1 v2 T+ \  gScience Oct 18, 2002
9 h7 h/ I) |6 }2 pThe transcriptional profiles of mouse embryonic, neural, and hematopoietic stem cells were compared to define a genetic program for stem cells. A total of 216 genes are enriched in all three types of stem cells, and several of these genes are clustered in ... 7 j0 [6 z) p: D6 Q3 S5 t

6 Z: v9 f, ~& F( m, _( _1 S0 Q: L1 `% F" V3 p" m0 R7 \2 d* N5 N3 W/ W
Changing potency by spontaneous fusion.! _+ A3 D9 T, d& h1 J6 S+ X
Nature Apr 04, 2002
" X/ H) x7 X2 t+ X. {Recent reports have suggested that mammalian stem cells residing in one tissue may have the capacity to produce differentiated cell types for other tissues and organs 1-9. Here we define a mechanism by which progenitor cells of the central nervous system ...
( J0 n; K' T) h: b6 [* c
/ ]1 @. @$ \3 ]* K8 l5 M# {3 B0 [5 u0 g+ r6 ~, d4 @2 ?3 X
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes.
, q3 ]9 E$ N0 P3 |" h0 o# ^2 t$ ^Nature Oct 30, 2003# \7 r& r# W4 e/ H* I
Recent studies have suggested that bone marrow cells possess a broad differentiation potential, being able to form new liver cells, cardiomyocytes and neurons. Several groups have attributed this apparent plasticity to 'transdifferentiation'. Others, ...
& P% ~4 I' ]6 q! W) R% D  x' n, s8 e
2 L% h4 X7 `9 J( |; n7 H4 u; N  U+ y+ ?3 E% D% n
Treatment of multiple myeloma.9 f5 c9 w3 O1 ^" l" D8 I( |5 f
Blood Dec 19, 20035 K+ I1 h# e, v) Z" }7 k0 ]. [5 i7 D
Autologous peripheral blood stem cell (PBSC)-supported high-dose melphalan is now considered standard therapy for myeloma, at least for younger patients. The markedly reduced toxicity of allotransplants using nonmyeloablative regimens (mini- ...
: d$ h) n# P( p$ x/ _* V
6 O( L* V' P5 Z. B, O- s- y* f8 g
8 m& J* a2 V8 r4 L; s$ BTransplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infar: x# J/ J5 W8 F. z$ z# M1 {! C/ U
Circulation Dec 10, 2002/ s* X! \% _# M5 t8 ]
BACKGROUND: Experimental studies suggest that transplantation of blood-derived or bone marrow-derived progenitor cells beneficially affects postinfarction remodeling. The safety and feasibility of autologous progenitor cell transplantation in patients ...
9 \2 M: R4 V5 {" {$ c% m
3 j8 \- p" D6 {+ s2 F4 B
+ L* [3 F% J) h; x) ?  H& [Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease.
2 {' k0 N. ^5 Y: r: O- w2 uScience May 04, 2000
# R' C. t* {* ~- [  tSevere combined immunodeficiency-X1 (SCID-X1) is an X-linked inherited disorder characterized by an early block in T and natural killer (NK) lymphocyte differentiation. This block is caused by mutations of the gene encoding the gammac cytokine receptor ...
8 {$ r; C. i- C& D+ x# n, C5 T( z4 r/ ^7 I
3 _+ C! W1 V- m; b" B( F7 }
Transplanted bone marrow regenerates liver by cell fusion.
& l; Z- l% t$ ]5 v' `( U. |: mNature Apr 24, 20034 m. C  {9 |0 u
Results from several experimental systems suggest that cells from one tissue type can form other tissue types after transplantation. This could be due to the presence of multipotential or several types of adult stem cells in donor tissues, or ... / y8 B8 y# R' E9 y# \& z9 b
" Q+ ]* M' E& \- {7 z. F
% l: h# o' u; T& z8 T1 w
Mobilized bone marrow cells repair the infarcted heart, improving function and survival.' S7 d3 {7 L9 j- U1 i+ r% N2 D
Proc Natl Acad Sci U S A Aug 29, 2001* K1 u; ?# V9 h; f$ a
Attempts to repair myocardial infarcts by transplanting cardiomyocytes or skeletal myoblasts have failed to reconstitute healthy myocardium and coronary vessels integrated structurally and functionally with the remaining viable portion of the ventricular ...
; e3 w6 C4 l6 q9 l" B
+ W# P) A& ]% _4 _8 _# ^: P% ~" }$ Q2 K, r  z& n% d  Q
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.3 W" _8 d4 ?7 g( u4 L4 |
Cell Jul 21, 19922 Y1 k, q. j! Y9 K4 I  W
Gene targeting in embryonic stem (ES) cells has been used to mutate the murine DNA methyltransferase gene. ES cell lines homozygous for the mutation were generated by consecutive targeting of both wild-type alleles; the mutant cells were viable and showed ...
, Y2 ]: x) T* \/ ]3 ~5 k7 }+ i+ n. Y8 W: @2 n- H
/ j  E' O7 I3 D1 {* j
Reciprocal control of T helper cell and dendritic cell differentiation.; S6 c$ n/ C. [, F7 Y
Science Mar 11, 1999* m; f0 E. r; {
It is not known whether subsets of dendritic cells provide different cytokine microenvironments that determine the differentiation of either type-1 T helper (TH1) or TH2 cells. Human monocyte (pDC1)-derived dendritic cells (DC1) were found to induce TH1 ...   D7 U* U+ a- G9 v) ~  E) L( r: [

* `2 V  l5 m  b+ ^% Q$ m% B$ M- n5 |$ @  Y9 e4 A2 T; }( o
Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial in; b! M8 O5 [: x, c. i+ a
Nature Apr 08, 2004& }6 U* M; m& k/ ?" U9 h0 l4 N1 h
The mammalian heart has a very limited regenerative capacity and, hence, heals by scar formation. Recent reports suggest that haematopoietic stem cells can transdifferentiate into unexpected phenotypes such as skeletal muscle, hepatocytes, epithelial ... 1 `- I, {) ^9 r6 `- M, l8 d( p, p' |

( U2 K8 F" }3 A2 ]0 T0 |
! K0 g' Z1 s, a8 m; U6 VHaematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium.
9 u) X# O* r+ G) N# x0 n1 dNature Apr 08, 20047 k( O: c, ?2 I
Under conditions of tissue injury, myocardial replication and regeneration have been reported. A growing number of investigators have implicated adult bone marrow (BM) in this process, suggesting that marrow serves as a reservoir for cardiac precursor ...
8 S! ?+ S1 f6 `9 b0 c! R  j* E$ Y9 ^% ~/ U+ A3 C( [/ H
) }! O( O/ V8 Z6 [( ~! B
Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells.& ^: p  l* D! u7 w& T! }3 a
J Clin Invest Jun 06, 2001
; a5 }( F; }" P1 QMyocyte loss in the ischemically injured mammalian heart often leads to irreversible deficits in cardiac function. To identify a source of stem cells capable of restoring damaged cardiac tissue, we transplanted highly enriched hematopoietic stem cells, ... 9 D) i$ Z  a1 `2 ]0 [: g% {

! D) H& C- r/ D- b  s& u* K3 Z" z% E; t% E
Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevent
- H+ u, ~% s2 [( V+ [Nat Med Apr 03, 2001
6 u( `6 |  K+ L  E2 bLeft ventricular remodeling is a major cause of progressive heart failure and death after myocardial infarction. Although neoangiogenesis within the infarcted tissue is an integral component of the remodeling process, the capillary network is unable to ... 6 r  r2 l0 e9 G2 a0 L% U+ u

6 d0 r6 t+ ^! g" X) N9 d1 B* }2 q' t7 U" c
Neurogenesis in the adult human hippocampus.
# X* L" d& X& d( N6 rNat Med Nov 30, 1998% Q8 n9 N4 O5 ^, E4 ^
The genesis of new cells, including neurons, in the adult human brain has not yet been demonstrated. This study was undertaken to investigate whether neurogenesis occurs in the adult human brain, in regions previously identified as neurogenic in adult ...
9 |* Q2 m0 T- d; z7 p3 o( _2 b) b9 L3 w/ L8 ?0 }, ~

( |# }5 H) q0 jAutologous bone-marrow stem-cell transplantation for myocardial regeneration.
- G1 p4 R* n, D% c# d. a1 @' u" bLancet Jan 08, 2003" }2 U9 [8 C0 ]. F2 L5 T& O; A6 [
Implantation of bone-marrow stem cells in the heart might be a new method to restore tissue viability after myocardial infarction. We injected up to 1.5x10(6) autologous AC133+ bone-marrow cells into the infarct border zone in six patients who had had a ... , O* y  ], {: |* u+ M

; i2 Q$ X& L' n; d

zorro

  是这个

fguw

最近看见一个大牛LAB 发的文章（ Elaine Fuchs, Ph.D.   ）
! r  b+ h2 t  u7 O+ n% U' R- h: C她应该是该属于领域顶尖的   Hair Follicle Stem Cells

zorro

回复 fguw 的帖子
* l) o5 `0 L. r# w: g, S8 G; P/ @- |( @; e
有关于她的文章可以传上来啊

fguw

麻烦告诉一下如何上传？

zorro

回复 fguw 的帖子" l  o7 p, ]$ K0 C6 }" b5 v

' R  V6 c  ~" s$ K( c0 ]8 J& l回复 右边点击高级模式 根据提示就可以了   上传好了  点击那个文件后 再输入右边方框中任意数字

fguw

回复 zorro 的帖子- M) O' i4 N8 W& _" y3 |

3 o  i" }: Y2 h, N& |* k( _skin nitche  review

fguw

回复 zorro 的帖子
- N" ?+ T+ W! ^% d' ]. h
1 }8 t( V, ^; f: }thanks, Zorro ,