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本帖最后由 grape 于 2011-8-25 08:05 编辑
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$ T+ u4 k3 a# p6 S以下是"Adult stem and transit-amplifying cell location. Histol Histopathol. 2006 Sep;21(9):995-1027"一文对Transit-amplifying cells (TAC)的解释：1 c8 N9 t: M, ?& A8 f* A" E* S
Transit-amplifying cells (TAC) are committed progenitors among the Adult stem cells (ASC) and their terminally differentiated daughter cells.# r5 O; @0 f8 f" Q
“过渡-扩增细胞（Transit-amplifying cells,TAC）”被认为是介于成体干细胞（Adult stem cells, ASC) 与其终末分化子细胞（terminally differentiated daughter cells）之间的一类祖细胞（progenitors）（或前体细胞）。, K! b/ ?7 x8 c' j) w' T
; B" o4 S' w5 v1 p* A: B# C2 d个人认为该细胞被命名为"Transit-amplifying cells"正是取"过渡、介于"之意，the cell have a transitional amplifying ability.
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源自4 _5 x7 L8 F' o9 ~# @3 W2 p
Histol Histopathol. 2006 Sep;21(9):995-1027.
& ^, Y7 J8 A: x. y, h J6 ]- UAdult stem and transit-amplifying cell location.8 F, ?/ H7 U. r8 ]9 J. N$ F
Díaz-Flores L Jr, Madrid JF, Gutiérrez R, Varela H, Valladares F, Alvarez-Argüelles H, Díaz-Flores L.: O' d- F: l5 U* F6 L
SourceDeparment of Pathology, Histology and Radiology, School of Medicine, La Laguna University, Canary Islands, Spain.$ A% f4 p \+ S6 x. A: Q) h
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Adult stem cells (ASC)--able to self renew and to intervene in maintaining the structural and functional integrity of their original tissue--can express greater plasticity than traditionally attributed to them, adopting functional phenotypes and expression profiles of cells from other tissues. Therefore, they could be useful to regenerative medicine and tissue engineering. The ASC reside in a specialized physical location named niche, which constitutes a three-dimensional microenviroment where ASC and TAC are protected and controlled in their self-renewing capacity and differentiation. The niche can be located near or far from the recruitment point, requiring a short or long-distance cellular migration, respectively. This paper briefly reviews the current status of research about ASC plasticity, transdifferentiation, fusion and functional adaptation mechanisms. Subsequently, ASC and TAC occurrence, characteristics and location have been considered in the skin, cornea, respiratory tract, teeth, gastrointestinal tract, liver, pancreas, salivary glands, kidney, breast, prostate, endometrium, mesenchyma, bone marrow, skeletal and cardiac muscle, nervous system and pituitary gland. Moreover, the role of cancer ASC has also been revised.3 E9 Y2 N5 |3 k" K6 A) l: [0 A
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PMID:16763950[PubMed - indexed for MEDLINE]
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Adult stem and transitamplifying cell location.pdf
(2.9 MB)
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发表于 2011-8-25 00:34
发表于 2011-8-25 10:50
