1998-nature-Dendritic cells and the control of immunity

andylee824

   B and T lymphocytes are the mediators of immunity, but their function is under the control of dendritic cells. Dendritic( H9 r1 f. Q. C. |7 ^
cells in the periphery capture and process antigens, express lymphocyte co-stimulatory molecules, migrate to4 s  n& V7 G4 z% P( K" }
lymphoid organs and secrete cytokines to initiate immune responses. They not only activate lymphocytes, they also
' A# Z, [! C1 v/ ^: O" C' K& Jtolerize Tcells to antigens that are innate to the body (self-antigens), thereby minimizing autoimmune reactions. Once
3 P/ E( q4 y0 d% n& oa neglected cell type, dendritic cells can now be readily obtained in sufficient quantities to allow molecular and cell
$ l: l  X3 o" I( R" k6 R% Xbiological analysis. With knowledge comes the realization that these cells are a powerful tool for manipulating the0 ?6 a2 A% ^0 [! ~. S
immune system.

andylee824

自己顶一下！

andylee824

自己顶一下！