MSCs Induce Resistance to Chemotherapy through the Release of PIFA

饶冠华

Mesenchymal Stem Cells Induce Resistance to Chemotherapy through the Release of Platinum-Induced Fatty Acids$ l5 w" ~- C9 i( U: |1 {( l
J.M.L. Roodhart, L.G.M. Daenen, E.C.A. Stigter, H.-J. Prins, J. Gerrits, J.M. Houthuijzen, M.G. Gerritsen, H.S. Schipper, M.J.G. Backer, M. van Amersfoort, J.S.P. Vermaat, P. Moerer, K. Ishihara, E. Kalkhoven, J.H. Beijnen, P.W.B. Derksen, R.H. Medema, A.C. Martens, A.B. Brenkman, and E.E. Voest
' T3 x: p8 w6 ?6 w$ T             " E! i. o- j- s. X$ W

9 I& Y  T* h1 Y1 O. J, F! zChemotherapy remains the primary treatment for most disseminated cancers. However, response to chemotherapy is often transient, and the development of resistance is one of the most significant obstacles to effective cancer therapy. Roodhart now show that mesenchymal stem cells (MSCs) activated by platinum-based chemotherapy secrete two unique fatty acids that, in minute quantities, confer resistance to multiple types of chemotherapy. This highlights an undesired role for stem cells in cancer treatment and reveals a potent effect of two relatively unknown fatty acids. Finally, the results reveal a therapeutic approach to enhance the clinical benefit of chemotherapy by blocking the release of these fatty acids from MSCs via inhibition of cyclooxygenase-1 or thromboxane synthase.  I+ u/ W+ W- ~) b
6 c/ ]3 u! L, s$ u) f0 p

xylophone

赞一个，这一方面的研究很有意义，为干细胞治疗应用提了个醒！