美科学家发现受者免疫系统控制着干细胞再生

naturalkillerce

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美科学家发现受者免疫系统控制着干细胞再生

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nauralkillerce导语：发表在Nature Medicine期刊上一篇新研究论文描述了不同类型的免疫系统T细胞交替地阻止和鼓励干细胞再生骨和组织，从而将干细胞移植受者的免疫系统在基于干细胞再生上的重要性变成引人注目的焦点。现编译如下：
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研究成果：6 y2 a2 K% F# Q4 n: `! H$ W9 t
在美国南加州大学Ostrow牙科学院颅面分子生物学中心开展的一项研究调查了含有骨缺陷的小鼠如何对骨髓间充质干细胞(bone marrow mesenchymal stem cell, BMMSC)介导的骨再生做出反应。# r0 N8 f9 D# l7 B

$ q1 j1 Z' Z+ d' _正常情况下，小鼠的T细胞产生一种炎性反应，引发细胞因子干扰素γ (INF-γ)和肿瘤坏死因子α (TNF-α)产生。它们攻击和杀死这些干细胞，从而阻止新骨产生。这就意味着尽管T细胞能够保护身体免受感染，但同时也能够阻止组织健康再生。: }) I' v3 P+ J9 f* V3 q

9 M  c" K. C) }6 H; P  s然而，当对这些小鼠灌注调节新T细胞(regulatory T-cells, Tregs)后，这些干扰性的INF-γ和TNF-α水平下降，从而增加骨再生和修复骨缺陷的比率。再者，在骨缺陷位点施加抗炎性药物阿司匹林也可增加BMMSC能够再生骨的比率。, V$ \' G' j( L0 e; \

) P# Z, ]" P3 L  O" G研究意义：* x9 @2 i- J! q7 C8 |$ b
博士后研究助理和第一作者Yi Liu认为这些发现清楚说明了T细胞在组织再生中发挥着以前没有认识到的作用，这也意味着科学家们在探索基于干细胞再生的可能性时需要将他们的关注重心调整到免疫系统上。
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! _1 ]4 x( S# ?6 \$ k& G5 o7 Q3 q进一步阅读：
# f  i! x$ i  @$ RT细胞的免疫反应水平决定干细胞的再生能力：http://www.stemcell8.cn/thread-49319-1-2.html- W1 @% q" i/ E2 K

3 |0 l" ]: @# E6 p- n2 @, Y原文信息：! D( I+ ?5 B; ^$ W7 r5 w
Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-α.
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7 \. b2 B0 _) G9 p7 _+ o/ ~Yi Liu, Lei Wang, Takashi Kikuiri, Kentaro Akiyama, Chider Chen, Xingtian Xu, Ruili Yang, WanJun Chen, Songlin Wang, and Songtao Shi.
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Nature Medicine, 2011 DOI: 10.1038/nm.254) I% `3 X. p2 ~0 F

1 Z3 |$ u7 I9 T* Khttp://www.nature.com/nm/journal/vaop/ncurrent/full/nm.2542.html

naturalkillerce

回复 naturalkillerce 的帖子# [+ |$ D3 H0 e# ~* E1 w- \

' b$ @: |+ |, s" A; r( ]$ b- y4 DRecipient's Immune System Governs Stem Cell Regeneration$ |, H4 ]5 a/ q0 T

0 _; d0 ^: i$ r6 i. L0 yScienceDaily (Nov. 20, 2011) — A new study inNature Medicine describes how different types of immune system T-cells alternately discourage and encourage stem cells to regrow bone and tissue, bringing into sharp focus the importance of the transplant recipient's immune system in stem cell-based regeneration.
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The study, conducted at the Center for Craniofacial Molecular Biology at the Ostrow School of Dentistry of USC, examined how mice with bone defects responded to bone marrow mesenchymal stem cell (BMMSC)-mediated bone regeneration.
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Under normal conditions, the mice's T-cells produced an inflammatory response and triggered the creation of cytokines interferon (INF)-gamma and tumor necrosis factor (TNF)-alpha. These attacked and killed the stem cells, preventing the production of new bone.
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7 Z1 N& m& i, ]8 N- F"Normally, T-cells protect us from infection," said Professor Songtao Shi, corresponding author for the study, "but they can block healthy regeneration from happening."1 W+ f/ x$ t. A) R. L# r
However, when the mice were given infusions of regulatory T-cells (Tregs), the levels of the interfering INF-gamma and TNF-alpha decreased, increasing the rate of bone regrowth and defect repair. Furthermore, administering the anti-inflammatory drug aspirin at the site of the bone defect also increased the rate at which the BMMSCs were able to regrow bone.
% A, R; Z! M0 p; T- lPostdoctoral Research Associate and lead author Yi Liu said the findings illustrate the previously unrecognized role of T-cells in tissue regeneration. They also highlight the need for scientists exploring the possibilities of stem cell-based regeneration to shift their focus to the immune system, she added.
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"Based on what we've found, this should be the direction of more research in the future," Liu said.: o0 X) e. Y, s; L3 ~/ `

8 {* }2 p0 \* J* F- w( @http://www.sciencedaily.com/releases/2011/11/111120134749.htm

hany2007

我把补充材料传上来，好文章

hany2007

全文在这里http://www.stemcell8.cn/thread-49319-1-2.html

一一

确实是一篇好文章，需要仔细的读，我粗略的看了一遍，调节性T细胞和阿司匹林为什么会在骨髓间充质干细胞骨修复过程中可以起到免疫调节作用，也就是说可以抑制其他免疫细胞导致的干细胞的凋亡。问题的关键是为什么？笼统的讲，是放低了免疫系统的监视，让异源性细胞溜了过去，还是注射的调节性T细胞或阿司匹林自身在干细胞的归巢中起了什么所用？如果不是骨修复，其他疾病的修复中，是否也存在免疫系统的干扰，答案是肯定的，但其中的信号通路是什么？或者抑制这种信号通路的办法又是什么？再后来就是临床应用的话，用一定的辅助手段，增加疗效，但又不可过度，以免犹如肿瘤寄宿下来，就是更麻烦的事情。

cuicuienya

下载不了啊* M5 C& q; n5 L0 c1 Y. S1 k& q9 R
怎么回事

细胞海洋

回复 cuicuienya 的帖子
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下载不要是迅雷

hkenb

这篇文章没有太大的新意吧，只是证明了一个意料中的结论而已。. r. [! {. Y$ J1 {, ?1 _