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Volume 148, Issue 45 f# k+ j3 A' @1 q4 ]7 Z( \" P
On the cover: Circadian rest:activity rhythms in animals are regulated by endogenous clocks that are typically synchronized to the day:night cycle. In this issue, Luo and Sehgal (pp. 765–779) identify JAK/STAT signaling as a component of the pathway that functions downstream of the clock in the regulation of rest:activity behaviors in Drosophila. They show also that circadian effects of JAK/STAT are modulated by a microRNA, miR-279. The cover image depicts a day:night adapted clock that turns on, or downregulates, JAK/STAT signaling, represented by a “Jack” from a deck of cards. The “Jack” is shown to hold a “sword”—a stem-loop shaped precursor microRNA. Artwork by Lili Guo.' z. S& f5 b8 e2 Q$ s& X2 S
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