|
- 积分
- 71
- 威望
- 71
- 包包
- 6
|
本帖最后由 细胞海洋 于 2012-3-26 13:34 编辑
+ H6 j' J* W8 V- A( I( ^( w
5 A; Y, U, ^. }; }7 w) uCellular DNA is subjected to continual attack, both by reactive species inside
4 F7 A5 ^; V& M( E8 Tcells and by environmental agents. Toxic and mutagenic consequences are8 C! y* a1 g4 C! y8 X# M
minimized by distinct pathways of repair, and 130 known human DNA repair
. _+ ]' M& w9 X: Ngenes are described here. Notable features presently include four enzymes that+ a, O8 i. S( @9 Y9 P
can remove uracil from DNA, seven recombination genes related to RAD51, and
$ K' p3 D' P3 O) vmany recently discovered DNA polymerases that bypass damage, but only one. @! K1 i4 _4 d4 L A5 _: N% w# f+ H% v
system to remove the main DNA lesions induced by ultraviolet light. More
; \5 R2 H* M4 v$ Fhuman DNA repair genes will be found by comparison with model organisms5 \ d$ H W3 B$ J* o
and as common folds in three-dimensional protein structures are determined.
J8 @* g4 J# N6 r3 P, `+ GModulation of DNA repair should lead to clinical applications including im-
; |/ q7 p% z# O4 X, ^provement of radiotherapy and treatment with anticancer drugs and an ad-2 r: d9 o0 |. J* r' c( T
vanced understanding of the cellular aging process./ D" }+ M/ O9 W# S
?: |7 P9 I/ J; L& O' R
[hide][/hide] |
附件: 你需要登录才可以下载或查看附件。没有帐号？注册
-
总评分: 包包 + 5
查看全部评分
|
发表于 2012-3-26 11:00
