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本帖最后由 细胞海洋 于 2012-4-2 08:50 编辑 + I* b4 N, k; y4 ^) M
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* H% Z. {# @1 _5 [Volume 19, Issue 3
( T9 |& u" f. Y5 }On the cover: Fluorescent proteins are power tools for cell biology. The 1 I4 j" F) }! f! K; Z! N
current challenges in the field include designing bright dimeric red fluorescent
' W, \) i" r/ v+ G) Z: `7 q" aproteins active in live cells. In this issue, Alford et al. (pp. 353–360)
4 d/ V5 W/ y" H$ }: R$ M- k. G5 ddescribe the development of such a system, a dimerization-dependent red
+ z% c/ w) @3 I4 z) x: E, y! lfluorescent protein, or ddRFP, comprised of non- or dim-fluorescent protein
% O9 T% S6 k5 n) W5 nmonomers. On the cover, streams of colorless solution pour from two distinct
6 f9 Y) e; `( O% I8 r3 D9 z4 mmonomers, symbolizing non- or dim-fluorescent entities. As the solutions pool
( Z2 m; R& A8 {: h P* j3 cand mix, a red color develops, representative of the fluorogenic signal
4 l# h3 p( ^8 t5 z& H0 [9 |- s- C# fgenerated upon heterodimer formation. The structure in the foreground is the 6 d" |' y- c: ~! ^- I' H
source of the red color: the complete ddRFP. Image created by Michael W. - Z f+ y9 T* e1 P+ K- ?# {, z, x
Davidson, Spencer C. Alford, and Robert E. Campbell.% t/ b. a0 o }8 G# B) I" B
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发表于 2012-4-2 00:29
