|
- 积分
- 17983
- 威望
- 17983
- 包包
- 26159
|
本帖最后由 细胞海洋 于 2012-4-2 08:50 编辑 3 y. H; q% R& ^4 Q% X1 |
& P4 E; Z! L$ n & G! A. P& }+ o: U& @, C
Volume 19, Issue 39 w" | [+ d* l2 P6 A
On the cover: Fluorescent proteins are power tools for cell biology. The 9 Q/ @9 Q7 O! |" P# X7 T
current challenges in the field include designing bright dimeric red fluorescent $ r9 C u, C% p u4 ^9 H
proteins active in live cells. In this issue, Alford et al. (pp. 353–360) ( o% H- _4 v' ~0 w$ B M8 Z$ h6 a
describe the development of such a system, a dimerization-dependent red
9 t3 L, w; n* O/ r0 N% c2 g- ?fluorescent protein, or ddRFP, comprised of non- or dim-fluorescent protein " A" B8 ~# S: T' T7 z) r5 N% s8 D
monomers. On the cover, streams of colorless solution pour from two distinct 2 E( ] o, e' H& b( b# a
monomers, symbolizing non- or dim-fluorescent entities. As the solutions pool
0 y+ q4 j- I$ U# ~- Xand mix, a red color develops, representative of the fluorogenic signal
% q, S& Q9 C8 s, _9 Ogenerated upon heterodimer formation. The structure in the foreground is the 9 m5 C( @4 p3 O5 C5 M
source of the red color: the complete ddRFP. Image created by Michael W.
( c( l7 A. C! x6 pDavidson, Spencer C. Alford, and Robert E. Campbell., k6 p1 \( B' s( S+ j
' d6 r. R5 @+ |" }& n" l
[hide][/hide] |
附件: 你需要登录才可以下载或查看附件。没有帐号？注册
-
总评分: 威望 + 20
包包 + 20
查看全部评分
|
发表于 2012-4-2 00:29
