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5 R/ b% ]" [9 P7 b/ t7 r, I On the cover: Nuclear pore complexes (NPCs) have long been assumed to be the sole gateway for macromolecular transport in and out of the nucleus. Speese et al. (pp. 832–846) provide evidence that, during Wnt-regulated synapse development, large ribonucleoprotein (RNP) granules carrying postsynaptic mRNAs are exported out of the nucleus through an alternative mechanism. The granules bud through the nuclear envelope. Although this mechanism has been previously demonstrated for the nuclear egress of herpes-type viruses, Speese et al. now suggest that exit through nuclear envelope budding is an endogenous mechanism for the export of large RNPs. The drawing, “Searching the way out of the nucleus,” represents a long journey through “brainscapes,” searching for a route out of the postsynaptic nucleus. In the end, the only way out was budding across the nuclear envelope. Ink drawing by Vivian Budnik, modified using ImageJ software
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发表于 2012-5-11 08:25
发表于 2012-5-11 09:14
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谢谢分享3 V' O( p# K* V