Survival gets more complicated

杨柳

CNTF and related proteins have been shown to promote the survival of motoneurons in two different settings: during embryonic development and after nerve injury in adults. Because the signal and the response are apparently the same in the two situations, a simple explanation is that embryonic and adult neurons use the same signaling pathways to promote survival. But on page 287, Schweizer et al. show that the simplest hypothesis is not always the correct one.9 p' F7 d6 n; p7 x5 G

( |6 y" {" N. }/ T; ^Earlier work had shown that CNTF activates the LIF receptor to promote neuronal survival, and that Stat-3 is an important downstream effector of the LIF receptor. The authors used Cre-mediated recombination in a transgenic mouse system to delete the Stat-3 gene in neurons of the facial nucleus and spinal cord. Surprisingly, the mice develop normally, with no neuronal defects. When the facial nerves of adult mice are damaged, however, they show a dramatic loss of motoneurons compared with wild-type controls. Therefore, Stat-3–mediated signaling appears to be essential for motoneuron survival after injury, but dispensible during embryonic development, suggesting that neurons use different pathways at different times to transduce the same signal.(Motoneurons are lost in injured mice lac)

txxxtyq

希望可以用些时间了~````  

beautylive

加油啊！！！！顶哦!!!!!  

aakkaa

干细胞研究还要面向临床

txxxtyq

脂肪干细胞

我心飞翔

@,@..是什么意思呀？  

aakkaa

干细胞产业是朝阳产业

txxxtyq

楼主也是博士后吗  

beautylive

支持一下吧  

123456zsz

爷爷都是从孙子走过来的。