Science:重新唤醒心脏的愈合系统（附原文）

坤明

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& H5 ^4 V9 J/ k9 v" X# C* O作者：美国科学促进会 来源：美国科学促进会 2012-11-165 N( x! t! n: ?; T. B( `  B

! G% O7 r  z; ?/ e# y科学家们确认了一组分子信号，这些信号可激活包围哺乳动物心脏的保护性的，及可能是修复性的组织层。这一发现可能最终会带来修复心脏损害的新策略。
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该被称作心外膜的组织在发育中会提供必需的生长因子和干细胞。它在成年期会处于休眠状态，但在心脏受损时会被重新激活。这一反应重新激活了那些在发育时帮助心脏生长的基因，但是引起这一过程的机制则一直是未知的。
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* t3 b- q3 Q1 Y' wGuo Huang及其同事在研究小鼠模型时发现，所谓的C/EBP转录因子激活了发育和损伤时的心外膜。阻断受伤心脏的心外膜中的C/EBP信号传导可减少炎症并改善心脏功能。. T& \$ {/ m5 [# S- z0 J/ K. @

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0 d& p* J$ `4 B" h- w  q6 b5楼原文 感谢jianlindunev 提供

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C/EBP Transcription Factors Mediate Epicardial Activation During Heart Development and Injury
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Guo N. Huang, Jeffrey E. Thatcher, John McAnally, Yongli Kong, Xiaoxia Qi, Wei Tan, J. Michael DiMaio, James F. Amatruda, Robert D. Gerard, Joseph A. Hill, Rhonda Bassel-Duby, Eric N. Olson- M9 B, U& }' q" B, h1 j% [

( V; J8 N  K* ]9 \  y! l$ yThe epicardium encapsulates the heart and functions as a source of multipotent progenitor cells and paracrine factors essential for cardiac development and repair. Injury of the adult heart results in reactivation of a developmental gene program in the epicardium, but the transcriptional basis of epicardial gene expression has not been delineated. We established a mouse embryonic heart organ culture and gene expression system that facilitated the identification of epicardial enhancers activated during heart development and injury. Epicardial activation of these enhancers depends on a combinatorial transcriptional code centered on CCAAT/enhancer binding protein (C/EBP) transcription factors. Disruption of C/EBP signaling in the adult epicardium reduced injury-induced neutrophil infiltration and improved cardiac function. These findings reveal a transcriptional basis for epicardial activation and heart injury, providing a platform for enhancing cardiac regeneration. ! e# @% O( d7 T& L& S

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坤明

http://www.sciencemag.org/conten ... 0-bd6a-11d729e161d3

jianlindunev

原文分享

jianlindunev

原文

haiq1984

sciencexpress与science 区别是什么？算是同一杂志吗？

haiq1984

sciencexpress 与science 有什么区别没有？

junxie

谢谢

haiq1984

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5 M  F# G! c" n* p  C* h' _0 g' M# e自问自答一下：ScienceXpress是Science杂志的在线预印版本。; R8 G' _& i1 K2 }( H# F8 a3 B, S
顺便再把supplementary奉上，很多方法还是不错的。

xiaoyurly

看看呀