Science:重新唤醒心脏的愈合系统（附原文）

坤明

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; ^: l! K/ C4 ?% Q3 G& h* J作者：美国科学促进会 来源：美国科学促进会 2012-11-16
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科学家们确认了一组分子信号，这些信号可激活包围哺乳动物心脏的保护性的，及可能是修复性的组织层。这一发现可能最终会带来修复心脏损害的新策略。: |+ K8 E' ^$ m" V& i
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该被称作心外膜的组织在发育中会提供必需的生长因子和干细胞。它在成年期会处于休眠状态，但在心脏受损时会被重新激活。这一反应重新激活了那些在发育时帮助心脏生长的基因，但是引起这一过程的机制则一直是未知的。
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Guo Huang及其同事在研究小鼠模型时发现，所谓的C/EBP转录因子激活了发育和损伤时的心外膜。阻断受伤心脏的心外膜中的C/EBP信号传导可减少炎症并改善心脏功能。
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( }+ _7 l9 R' \' |$ J; J- p5楼原文 感谢jianlindunev 提供

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C/EBP Transcription Factors Mediate Epicardial Activation During Heart Development and Injury
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% _6 }$ Z6 M' i3 x" cGuo N. Huang, Jeffrey E. Thatcher, John McAnally, Yongli Kong, Xiaoxia Qi, Wei Tan, J. Michael DiMaio, James F. Amatruda, Robert D. Gerard, Joseph A. Hill, Rhonda Bassel-Duby, Eric N. Olson
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+ @( y; M$ I5 k5 `: V; FThe epicardium encapsulates the heart and functions as a source of multipotent progenitor cells and paracrine factors essential for cardiac development and repair. Injury of the adult heart results in reactivation of a developmental gene program in the epicardium, but the transcriptional basis of epicardial gene expression has not been delineated. We established a mouse embryonic heart organ culture and gene expression system that facilitated the identification of epicardial enhancers activated during heart development and injury. Epicardial activation of these enhancers depends on a combinatorial transcriptional code centered on CCAAT/enhancer binding protein (C/EBP) transcription factors. Disruption of C/EBP signaling in the adult epicardium reduced injury-induced neutrophil infiltration and improved cardiac function. These findings reveal a transcriptional basis for epicardial activation and heart injury, providing a platform for enhancing cardiac regeneration. ' X  l/ J; m" E% e* a
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坤明

http://www.sciencemag.org/conten ... 0-bd6a-11d729e161d3

jianlindunev

原文分享

jianlindunev

原文

haiq1984

sciencexpress与science 区别是什么？算是同一杂志吗？

haiq1984

sciencexpress 与science 有什么区别没有？

junxie

谢谢

haiq1984

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8 J* h! J) L  I4 m3 D自问自答一下：ScienceXpress是Science杂志的在线预印版本。' E! U% J8 o8 i  J
顺便再把supplementary奉上，很多方法还是不错的。

xiaoyurly

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