PDF电子书：Cancer Epigenetics - Methods and Protocols （2012）

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ISSN 1064-3745 e-ISSN 1940-60294 r" f8 ~1 k0 Q) v/ l  Q
ISBN 978-1-61779-611-1 e-ISBN 978-1-61779-612-8
& ?7 d% w7 u: c( j8 J- K5 xDOI 10.1007/978-1-61779-612-88 X: x& M: j5 p1 _3 W, i' l
Springer New York Dordrecht Heidelberg London/ ~% a+ Z) _% \( C" m( V
Library of Congress Control Number: 2012931559
# k2 X3 ]8 O/ e' j© Springer Science+Business Media, LLC 2012
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Contents
' P3 l' I/ A* k: g' vPreface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
; C. B9 @3 ]8 P3 R. . . . . . . . . . . .         v
$ g2 r$ K5 _! ]0 v: r6 RContributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 g" m4 G! Z: U  E( K$ e
. . . . . . . . . .        xi
  y/ e" M2 p3 q: [$ ~* R% a, Z+ H* YPART I   EARLY EPIGENETIC EVENTS IN CANCER! c5 d# k/ B$ Q6 e: s* `
1   Epigenetic Markers of Early Tumor Development . . . . . . . . . . . . . . . . . . . . . .      
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Ramona G. Dumitrescu, ]/ Q/ e1 |: P6 f+ y/ p# I
2   Epigenetics of Solid Cancer Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . / B0 W7 x" B5 f7 B
. .       15
# r( R) G. G' O: O  {0 wAlok Mishra and Mukesh Verma5 `8 u1 c: S- Q( Q' ?# f
PART II    CANCER SPECIFIC TYPE EPIGENETIC CHANGES
/ I. D& \, F8 k/ _! }% g5 v3   DNA Methylation and Histone Modifications in Breast Cancer . . . . . . . . . . . .       35
( P8 [, e3 ]% R8 _& D4 u0 B3 iRamona G. Dumitrescu
. M! f0 }$ x' p4  DNA Methylation Changes in Prostate Cancer . . . . . . . . . . . . . . . . . . . . . . . .      5 C* L" w2 [" f5 ?, s! h
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Wolfgang Goering, Michael Kloth, and Wolfgang A. Schulz3 W1 `2 E3 ?+ {% p& L3 m
5   DNA Methylation in Promoter Region as Biomarkers
7 s1 Y% Y5 f* w9 f$ k/ \in Prostate Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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1 l8 e7 Y2 }( Y: F9 iMihi Yang and Jong Y. Park) R. ]+ W$ u& s
6   Epigenetics of Bladder Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 n. t- m1 _$ L
. . . .     111% O9 U4 U$ K* ^" m
Wun-Jae Kim and Yong-June Kim
4 E- g& x9 D! a' A- e' k7  Epigenetics in Myeloid Malignancies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . & d/ S5 Q+ U& B! P$ I0 K: i8 p( ]
. .    119
4 J# Q0 t. a& d( Y3 j5 @. f1 DStefan Deneberg
. O# G' V3 r7 i, S8   The Epigenetics of Brain Tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . / Q; z; w3 W6 }- s8 g; {; f
. .     139/ Q; o! h. w. P4 I4 c( H1 d6 }
Adrian M. Dubuc, Stephen Mack, Alexander Unterberger, Paul A. Northcott, and Michael D. Taylor  A+ j1 T0 {! |1 H6 O! J6 k
9  DNA Methylation Changes in Cervical Cancers . . . . . . . . . . . . . . . . . . . . . . .    155+ c- i7 ]) m/ f3 z; X& s
Qiang Lu, Dehua Ma, and Shuping Zhao
8 z( ^$ Z# W: |/ B2 @9 D: t10   Epigenetics of Colon Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Sharad Khare and Mukesh Verma5 J2 G* f- r1 n: N; W& @
11  Promoter Methylation in Head and Neck Tumorigenesis. . . . . . . . . . . . . . . . .    1878 W6 r' u. _! ~6 R: U- v
Josena K. Stephen, Kang Mei Chen, Shaleta Havard, Glynis Harris, and Maria J. Worsham* u. a. P, l$ L! r1 F+ p
12   Epigenome and DNA Methylation in Oral4 I$ ~# k$ q% i; a
Squamous Cell Carcinoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . % N9 k+ h  z% ]/ H$ S
.    207
! `7 t- j& i7 ?. v/ EMario Pérez-Sayáns García and Abel García-García5 b3 o: v7 |1 F) U; d9 Z( m
Mario Pérez-Sayáns García and Abel García-García
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- e' A8 J: O6 B0 uviii           Contents
% j7 L& K+ ~6 R/ g1 j4 L0 N13   Clinical Implications of Epigenetic Alterations in Human
. b1 f+ v9 R2 \4 zThoracic Malignancies: Epigenetic Alterations in Lung Cancer . . . . . . . . . . . .     221. D% E4 X* H9 `9 y/ e
Keiko Shinjo and Yutaka Kondo0 r! i2 F7 e# s1 S( f
14   The Role of MicroRNAs in the Management of Liver Cancer . . . . . . . . . . . . .     241
; S6 c4 T* z, g0 P% ^8 VKrishna K. Banaudha and Mukesh Verma
2 R& B' S& f5 X15   Epigenetics in Ovarian Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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L.M.S. Seeber and P.J. van Diest4 I7 Y+ k4 H) \5 o2 K
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PART III   METHODS AND TECHNOLOGIES USED FOR EPIGENETIC CHANGES’ DETECTION
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16   DNA Methylation in Pancreatic Cancer: Protocols! C+ T# m/ C) q7 A  Q
for the Isolation of DNA and Bisulfite Modification . . . . . . . . . . . . . . . . . . . .     273
# F$ u' h/ y- ~+ qKatja Biewusch, Marie Heyne, Robert Grützmann, and Christian Pilarsky  E. Q4 d4 Z, B/ J3 ~
17   Detection and Analysis of DNA Methylation by Pyrosequencing . . . . . . . . . . .     281
2 c) u1 v' _+ y, oHilary A.A. Colyer, Richard N. Armstrong, Daniel J. Sharpe, and Ken I. Mills" Z0 L/ V( W3 M' B0 V
18   Screening for miRNA Expression Changes Using Quantitative
, I0 ^' X( q$ zPCR (Q-PCR) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . & O9 }5 `6 ]* Z6 ]+ c
. . . .    2936 P3 Y" p4 l- f1 G% M; f
Richard N. Armstrong, Hilary A.A. Colyer, and Ken I. Mills
( v. L5 }6 y$ a3 L19   Genome-Wide Methylation Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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) n& O$ j8 y  QAlexander Unterberger, Adrian M. Dubuc, and Michael D. Taylor. C3 u  ]% n" j. ]% i
20  Microarray for Epigenetic Changes: Gene Expression Arrays . . . . . . . . . . . . . .   319; U: N9 I" K. G3 `) l) w! u
Hilary A.A. Colyer, Richard N. Armstrong, and Ken I. Mills
) d& D- l6 T$ v* `) n21  Detecting DNA Methylation Using the Methylated CpG
2 z: o3 @' Z6 s  {/ a8 ^4 EIsland Amplification and Microarray Technique. . . . . . . . . . . . . . . . . . . . . . . .     % T+ x* S$ T- k9 p
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Hilary A.A. Colyer, Margaret Dellett, and Ken I. Mills4 X  {- r  J3 D* t% E2 X; L
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PART IV  FACTORS THAT INFLUENCE THE EPIGENETIC CHANGES IN CANCER
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22   Nutrigenomics: Implications for Breast and Colon Cancer Prevention . . . . . . .     343
2 S3 `9 O# Y6 @. pGabriela Riscuta and Ramona G. Dumitrescu) n" F( A# ?5 E: m! C' k' E
23   Dietary and Lifestyle Factors of DNA Methylation . . . . . . . . . . . . . . . . . . . . .     ; K9 Z& [4 r6 Z3 F6 m. e4 j
359
" ?+ q1 \1 O8 rUnhee Lim and Min-Ae Song4 w$ M. `0 o2 c9 @% j% i- Y0 o
24   Diet, Epigenetics, and Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
3 z$ t5 t5 W! |! r9 V3 r, V4 p. . . . .     377
1 l. U( @$ g) E( ?L. Joseph Su
7 D8 t' P0 O/ ?0 W6 Y25   Role of Epigenetics in Cancer Health Disparities . . . . . . . . . . . . . . . . . . . . . . . 8 J& E9 J# h/ u2 h  q
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  D. [- J  X# PSulma I. Mohammed, Sanya Springfield, and Rina Das
/ g% F* o4 B4 _" _8 b. g26   Multifactorial Etiology of Gastric Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . 9 ^, N( q4 A5 D& Q$ Y. S
. .     4113 w+ x: D  U' [
Jovanny Zabaleta- }( Q; Q; P3 V, L; J
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Contents             ix
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PART V    EPIGENETIC EPIDEMIOLOGY
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$ W8 q( k" p# E: w27  Epigenetic Epidemiology for Cancer Risk: Harnessing Germline6 Y. Z' u: e6 r3 @$ J0 u
Epigenetic Variation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . " F. {! V, I: M5 p
. . . . .    4392 F' c+ u8 j2 X! t6 \  y
Kevin Brennan and James M. Flanagan
! ~( l# x- H) ~28   Epigenetic Biomarkers in Cancer Epidemiology. . . . . . . . . . . . . . . . . . . . . . . .    2 m5 ~  H: D5 M
467: |, H% R/ H7 c2 \% q& i" C" @# f
Mukesh Verma& f! X" w/ ~# Y
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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