PDF电子书：Nanotechnology for Nucleic Acid Delivery (Springer MMB-Vol948, 2013)

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/ ^$ N/ e3 \& Q8 _9 \4 t( c1 ?Nanotechnology for Nucleic+ v1 ~0 a7 _. h  u
Acid Delivery
! b# S$ Z, L4 _1 n0 X5 V0 jMethods and Protocols
# L4 Z2 b' v5 e% H% F. k" v* x5 YEdited by' i5 |! R; V' t4 X
; V( w0 _! Z  O% o, U$ B' @
Manfred Ogris$ X( n1 r: \" f- F
Department of Pharmacy,6 a/ Q* G* {1 v* E) U  V2 }& ~8 x
Ludwig-Maximilians-University Munich, Munich, Germany4 w$ I8 E4 t, Q/ n- v! N' J
David Oupicky5 _( C. |- `9 Z; F/ n
Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI, USA& G: t/ P: J! z( d8 E9 }; p3 j8 u
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Contents
0 T- r7 F3 o7 `& ?( z) BPreface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v$ r9 G, j' j4 i
Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix
4 x# w: x; @3 b$ P, f2 L# p9 D1 Toxicological Aspects for Nanomaterial in Humans . . . . . . . . . . . . . . . . . . . . . 1
2 h( I, o4 v, [2 _; Q3 LMaria Dusinska, Zuzana Magdolenova, and Lise Marie Fjellsbø
$ O( D6 V/ _$ {* w1 [# s9 r2 Lactate Dehydrogenase Assay for Assessment of Polycation Cytotoxicity . . . . . 13
) Z4 n- u8 ]0 w5 N  KLadan Parhamifar, Helene Andersen, and S. Moein Moghimi4 J( T/ T2 ?1 b" F0 Y6 D9 j6 s
3 Combined Fluorimetric Caspase 3/7 Assay and Bradford Protein( o6 j$ e2 h7 f9 q+ ]9 ~5 ]3 H) B8 w
Determination for Assessment of Polycation-Mediated Cytotoxicity . . . . . . . . 23, J" h) o! r! @6 k$ d& d6 M( }
Anna K. Larsen, Arnaldur Hall, Henrik Lundsgart, and S. Moein Moghimi- [5 l! u% I' |, I8 o" g7 g
4 Anti-PEG IgM Production via a PEGylated Nano-Carrier System2 Q1 D0 x/ W' d& V- U
for Nucleic Acid Delivery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35+ t7 j( ~9 H' u. m5 B- ]$ j
Masako Ichihara, Naoto Moriyoshi, Amr S. Abu Lila, Tatsuhiro Ishida,
+ i  _( @1 {( E: e; X: B1 z; vand Hiroshi Kiwada
! t+ A( M. [9 C9 ]: w# f* H5 Near-Infrared Optical Imaging of Nucleic Acid Nanocarriers In Vivo . . . . . . . 49
! U3 b0 P. t  Q3 F7 ~  N1 w( E: JClaire Rome, Julien Gravier, Marie Morille, Gilles Divita,! q, g" B. e( M( f
Anne-Laure Bolcato-Bellemin, Véronique Josserand, and Jean-Luc Coll+ k. Y, @& ~4 l! O& l2 Q: _
6 Lipids for Nucleic Acid Delivery: Synthesis and Particle Formation . . . . . . . . . 67* Z3 I% V& Y  F5 y1 S
Michel Bessodes and Nathalie Mignet5 o0 G  B9 K) R# J0 X8 a- Q; `: v
7 Histidine-Rich Cationic Amphipathic Peptides for Plasmid DNA, n" G) O* e# b" _" B
and siRNA Delivery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85
3 K3 G: E0 i: S" z+ I% qAntoine Kichler, A. James Mason, Arnaud Marquette,* B/ ^9 |, x% D' J. m" H
and Burkhard Bechinger
2 ^$ X$ x3 J/ a7 _& Q8 Synthesis of Polyethylenimine-Based Nanocarriers for Systemic Tumor
4 R# g+ F- Y  P, RTargeting of Nucleic Acids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 105" m% T$ \3 l5 @. j
Wolfgang Rödl, David Schaffert, Ernst Wagner, and Manfred Ogris
( E1 B. V* c! f7 V8 p1 q9 Synthesis of Bioreducible Polycations with Controlled Topologies . . . . . . . . . . 121
  R8 A% U" Y! v7 JYe-Zi You, Jun-Jie Yan, Zhi-Qiang Yu, and David Oupicky
/ K& K/ [" h( ?, v# `8 x+ {10 Lyophilization of Synthetic Gene Carriers . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133
6 N+ @" G. a1 Z- @: CJulia Christina Kasper, Sarah Küchler, and Wolfgang Friess
+ Q4 m6 l$ ]* t/ o, ]9 R11 Surface-and Hydrogel-Mediated Delivery of Nucleic Acid Nanoparticles . . . . . 149! T- S3 J' |; b& m1 T7 P5 g
Angela K. Pannier and Tatiana Segura8 {5 A2 R( g' _( K: w
12 Layer-by-Layer Assembled Gold Nanoparticles for the Delivery7 X2 Y# N: R! I/ g
of Nucleic Acids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1716 J+ D* v9 u" H5 `2 ^+ T  D$ I
Eva-Christina Wurster, Asmaa Elbakry, Achim Göpferich,. V, S: Q: ^/ D! `' E% q
and Miriam Breunig( c# ^# y! ?( M. q  N* A! j3 R
viii Contents
  ~  |; m( j! z13 In Situ AFM Analysis Investigating Disassembly of DNA Nanoparticles
  n  X# k  V+ z/ {! Jand Nano-Films . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 183
. P. `: T9 W" J# D4 q4 a/ Y2 GYi Zou, Lei Wan, Jenifer Blacklock, David Oupicky, and Guangzhao Mao
; A  E0 x0 n* Z6 ^14 Enhancing Nucleic Acid Delivery with Ultrasound and Microbubbles . . . . . . . 1955 t8 ^# w" I8 j  S4 O0 L* o* f+ |- S
Steven K. Cool, Bart Geers, Ine Lentacker, Stefaan C. De Smedt,
% t  e6 w8 b3 Nand Niek N. Sanders) q* R$ ]6 _1 O# o3 g
15 Magnetic and Acoustically Active Microbubbles Loaded with Nucleic Acids2 |! b1 k7 l* P% M: {0 R
for Gene Delivery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 205$ @& M: z' ~; j6 P2 e7 T8 T, P
Dialechti Vlaskou, Christian Plank, and Olga Mykhaylyk, G6 Y( D5 |* m$ n
16 Synthesis of Lipidic Magnetic Nanoparticles for Nucleic Acid Delivery . . . . . . 243! o  P. B2 b1 |) |
Yoshihisa Namiki3 W+ E8 p8 w( M$ I. ?
17 Lipopeptide Delivery of siRNA to the Central Nervous System . . . . . . . . . . . . 251
2 D7 w: B- S1 K% [! Q# W+ G% qMark D. Zabel4 y' _+ Y6 Y$ F* E$ u* H
18 Flow Cytometry-Based Cell Type-Speci fi c Assessment of Target Regulation
; E& Z  q( H6 hby Pulmonary siRNA Delivery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 263
' c7 j! J% {& Z: c( i3 kOlivia M. Merkel, Leigh M. Marsh, Holger Garn, and Thomas Kissel
6 [7 M1 u$ V& F7 o. o19 Liver-Targeted Gene Delivery Through Retrograde Intrabiliary Infusion. . . . . 275( j# @- l) e# h5 I8 t8 y2 T
Xuan Jiang, Yong Ren, John-Michael Williford, Zhiping Li,) T, M: ?- B  n; D( U' u4 F
and Hai-Quan Mao
$ O! t8 L  \' J$ V% m, }; ]1 ZIndex . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 285
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