PDF电子书：Stem Cell Engineering Principles and Applications 2011

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2 D5 {! u! H' o% _0 OBook Title
0 v* z! h* f" m2 |Stem Cell Engineering
5 o7 S, u: _9 I$ z; QBook Subtitle6 i: U, B  W, [! a/ O- K7 u: e. p
Principles and Applications
7 _5 |' @* C: l" O9 OCopyright9 N" z! l# D- ]
2011% b' Y+ E; ]7 a1 h" K! O+ i
DOI
+ s4 C4 I1 o% X' C1 g& M7 [7 \10.1007/978-3-642-11865-4
( Y' R0 x8 l3 `  Z! g- `5 E# YPrint ISBN% E- y/ u" b* K  P
978-3-642-11864-7
' e( u& r% W& E$ }; FOnline ISBN
$ F1 E% L, p# ]( }' V7 d( P978-3-642-11865-4
4 [3 w& F5 P/ z3 ]' l. H1 y) _Publisher. r! Y8 f# |+ y0 b. i
Springer Berlin Heidelberg4 h, O! E" }; g6 g0 G; u( T: D, B" a
Copyright Holder
# g2 {) s* e% \; l, ~Springer-Verlag Berlin Heidelberg
; B4 \1 \" O$ [' M' \
0 Y  T  @9 s! ~& D: v- Reviews Engineering Approaches in Stem Cell Research
0 T6 @: o5 P, O/ [- Provides a solid reference for researchers and advanced graduate student
  j7 X) C+ ?+ {: s+ O& [/ N$ PThe potential of stem cells for healing and disease prevention in all fields of medicine is tremendous and has revolutionized the high-tech biomedical research. In this book, many of the most prominent researchers discuss the challenging topics of stem cell engineering, for example: Ethical issues of stem cell research; technological challenges, stem cell growth and differentiation, therapeutic applications, bioreactors and bioprocesses, high throughput and microfluidic screening platforms, stem cell identification and sorting, intercellular signaling and engineered niches, novel approaches for embryonic and adult stem cell growth and differentiation, stem cells and drug discovery, screening platforms. Stem Cell Engineering offers valuable background and reference for both the public and professionals including industrial staffers, faculty, researchers, engineers, students and scientific journalists.
5 p5 |' ~) X- F1 vContent Level » Research
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+ P/ l; K1 d6 @$ p9 EKeywords » bioreactors - cell expansion - differentiation - drug discovery - embryonic stem cell growth - stem cell growth
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3 ?" s5 c* f1 Q! C" U3 U* xRelated subjects » Biomedical Engineering - Biotechnology - Cell Biology
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Contents9 o* K  h$ R( ~6 Y+ y
Part I Instead of an Introduction – The Emperor’s New Legs" ]" H. G( i; p% z
The Emperor’s New Body: Seeking for a Blueprint of Limb1 V0 V$ t4 ]# D! E  c& \  Q
Regeneration in Humans . . . . . . . . . . . . . . . . . . . . . . . . . . 36 o8 D9 w$ {: L
Ilya Digel and Aysegül Temiz Artmann
1 {" k, M6 D, u% FPart II Basics and Basic Research* _. g& Y8 d6 b1 X3 |* Z7 X
Engineering the Stem Cell Niche and the Differentiative Microand
% j1 l  G. Q* `9 l( N* OMacroenvironment: Technologies and Tools for Applying1 W/ i5 ]; }; Y- E9 I
Biochemical, Physical and Structural Stimuli and Their Effects7 b  U, i. Z  c* G5 i! k
on Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41' e. L& C4 d6 O- t2 ^2 Y& [/ T
Paolo Di Nardo, Marilena Minieri, and Arti Ahluwalia/ N$ g9 |( C7 o$ |* s0 H
Differentiation Potential of Adult Human Mesenchymal Stem Cells . . 61
& H) F$ [3 }1 e# _8 mEdda Tobiasch' t& N5 P' N  \# L' k8 P
The Potential of Selectively Cultured Adult Stem Cells( ?1 s0 f. Z' C+ ]5 |; T* ^
Re-implanted in Tissues . . . . . . . . . . . . . . . . . . . . . . . . . . . 79
1 \6 k9 z% B( d* k2 M4 f2 WIsgard S. Hueck, Martin Haas, Rita Finones, Jane Frimodig,
' M* ^# E3 Q6 N. Vand David A. Gough5 C' I& x" p6 ~5 e; `5 A+ q
Enhanced Cardiac Differentiation of Mouse Embryonic Stem" o9 H9 L3 h1 U& X% B: {, }1 j3 d9 a" y
Cells by Electrical Stimulation . . . . . . . . . . . . . . . . . . . . . . . 1199 M5 Y& R3 r  J
Paul R. Bidez III, J. Yasha Kresh, Yen Wei, and Peter I. Lelkes* _" G2 K# E! B6 Z) z
The Therapeutic Potential of ES-Derived Haematopoietic Cells . . . . . 143
+ p* ~1 S1 E* P$ C1 tSabrina Gordon-Keylock and Lesley Forrester- k3 l! ~5 k. q
Genetic Modification of Human Embryonic and Induced0 [- N3 g. d) R& b
Pluripotent Stem Cells: Viral and Non-viral Approaches . . . . . . . . . 159% D$ l1 U2 B2 L) I3 _) h
Nicole M. Kane, Chris Denning, and Andrew H. Baker
: k# [* G. ^+ _7 tThe Immune Barriers of Cell Therapy with Allogenic Stem
( S, q) h' }$ m8 w  `( eCells of Embryonic Origin . . . . . . . . . . . . . . . . . . . . . . . . . 181( c8 O0 z: A1 }  y# R$ O
Olivier Preynat-Seauve, Karl-Heinz Krause, and Jean Villard
* I4 ]) X) p7 u# S: \+ Fxxxi
9 f4 b, |1 o* t2 |* E, Exxxii Contents1 C7 G2 V. Z' L# [% u9 Y/ O
Reponses of Mesenchymal Stem Cells to Varying Oxygen' V8 P) z& p* i9 w' a9 z
Availability In Vitro and In Vivo . . . . . . . . . . . . . . . . . . . . . . 1995 L; X# B' q0 M
Frank R. Kloss, Sarvpreet Singh, and Günter Lepperdinger
: @( S! d6 v/ m8 H! e) o7 ]% _Endothelial Progenitor Cells and Nitric Oxide: Matching% ]/ S; q0 B. j) [. p
Partners in Biomedicine . . . . . . . . . . . . . . . . . . . . . . . . . . . 213
& ?; \* q5 ]( u- C  t( R# LStefanie Keymel, Burcin Özüyaman, Marijke Grau, Malte Kelm,
& Z" O. u  O8 I! P% l% Cand Petra Kleinbongard' V2 e& s3 I$ Y, P) k
Skeletal Stem Cells and Controlled Nanotopography . . . . . . . . . . . 247
5 b  b! r' O7 \3 oMatthew J. Dalby and Richard O.C. Oreffo5 c* O. A5 g  u' X
Part III Clinical Applications
8 Q3 R! q! u7 T* o4 hCells and Vascular Tissue Engineering . . . . . . . . . . . . . . . . . . . 261, ^$ j7 Y9 E: s6 j2 R8 C8 y. {
John Paul Kirton, Tsung-Neng Tsai, and Qingbo Xu9 }6 l3 \2 P1 z9 t8 L
Endothelial Progenitor Cells for Vascular Repair . . . . . . . . . . . . . 297- z: o/ R: a0 [9 o: s$ G: u& V
Melissa A. Brown, Cindy S. Cheng, and George A. Truskey
1 G# u3 Q  y* l" j  s& `Regenerating Tubules for Kidney Repair . . . . . . . . . . . . . . . . . 321! a. e- T* f0 o/ H1 n8 R4 D& |0 E1 E
W.W. Minuth, L. Denk, and A. Roessger3 a. ^' c$ t3 O8 Y6 h; Z
Stem Cells in Tissue Engineering and Cell Therapies7 Z: k2 Z5 B6 v+ g8 a
of Urological Defects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 345- c6 L9 M" l4 N0 f9 [% h  y
Christoph Becker, Katrin Montzka, and Gerhard Jakse
  [) g# E: }7 RBio-synthetic Encapsulation Systems for Organ Engineering:
5 q0 a( k) H) V+ bFocus on Diabetes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 363
" G8 N5 Q7 |8 V+ [3 G3 D2 k" nRylie A. Green, Penny J. Martens, Robert Nordon,
! @; v. p& A2 |2 _$ nand Laura A. Poole-Warren0 {9 {, a! c% F0 C# J6 C/ b
Stem Cell Engineering for Regeneration of Bone Tissue . . . . . . . . . 383" ?# v( j' d$ t8 W! ]
Michael Gelinsky, Anja Lode, Anne Bernhardt, and: A; K5 C+ I  X* |' `. {/ z0 z
Angela Rösen-Wolff
; S3 n- R7 \6 ~" z; `. ~Part IV Techniques and Applications
3 R: ?2 A/ H6 s3 ?7 t' @, G- sBuilding, Preserving, and Applying Extracellular Culture! d8 T. D- m1 ~/ L
Integrity Using New Cell Culture Methods and Surfaces . . . . . . . . . 4037 w- X; j! R+ P) ?2 t# b
Thomas Brevig, Robin Wesselschmidt, and Masayuki Yamato
0 w0 n5 B( A  ~5 X9 `# AFabrication of Modified Extracellular Matrix
; f' n5 C$ t1 `for the Bone Marrow-Derived Mesenchymal Stem Cell5 R  J+ `7 k/ b# B; w
Therapeutics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 417
4 r$ b% u/ g7 {7 ^; k4 eHwal (Matthew) Suh% b2 C& \; V4 r9 H: v" g& |
Neural Stem Cells: From Cell Fate and Metabolic Monitoring# `% U' Y- Y9 E
Toward Clinical Applications . . . . . . . . . . . . . . . . . . . . . . . . 435
8 ]1 t( v) `6 W" G7 L2 q4 _Jan Pruszak, Máté Döbrössy, Jochen Kieninger, Kuppusamy( Y! c  g+ i1 r: h3 b9 l3 {
Aravindalochanan, Gerald A. Urban, and Guido Nikkhah
3 d+ I  |+ V: O0 i9 n7 C; N3 I/ uContents xxxiii8 t7 L) {' v- l' }
Adult Stem Cells in Drug Discovery . . . . . . . . . . . . . . . . . . . . 457
; P2 k' h) P+ E) h+ R& @* SStefan Golz, Andreas Geerts, and Andreas Wilmen
  J* B+ \! P/ r1 C0 B5 LEmbryonic Stem Cells as a Tool for Drug Screening and Toxicity Testing 473
3 H1 G- W& i; q! J; v: Q' A1 k1 q1 mBernd Denecke and Silke Schwengberg! C* o9 c2 U. w+ }
Embryonic Stem Cells: A Biological Tool to Translate the
7 u: H: S+ C( k7 r! @6 t) |6 E% }Mechanisms of Heart Development . . . . . . . . . . . . . . . . . . . . 5016 b3 p  U, g4 \. D
Omonigho A. Aisagbonhi and Antonis K. Hatzopoulos" ^* w/ f+ s/ ?2 s
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 521

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