利用丝编织物和纤维素生物材料以利于干细胞修复关节软骨损伤

tjbone

利用丝编织物和纤维素生物材料以利于干细胞修复关节软骨损伤
$ w! X2 S: h8 Q7 K: I  \Silk and Cellulose Biologically Effective for Use in Stem Cell Cartilage Repair4 D+ z: c2 N% X  @7 f2 Q5 T# g5 ^
May 7, 2013 — Over 20 million people in Europe suffer from osteoarthritis which can lead to extensive damage to the knee and hip cartilage. Stem cells offer a promising way forward but a key challenge has been to design a 'smart material' that is biologically effective for cartilage tissue regeneration. Now researchers have identified a blend of naturally occurring fibres such as cellulose and silk that makes progress towards affordable and effective cell-based therapy for cartilage repair a step closer.! N/ v0 S+ z6 d$ V; K: D, g; G# }" F
The EPSRC-funded study, published in Biomacromolecules and undertaken by University of Bristol researchers, explored the feasibility of using natural fibres such as silk and cellulose as stem cell scaffolds -- the matrix to which stem cells can cling to as they grow.. A. V# U+ R" l, V9 w0 f
Both cellulose and silk are commonly used in textiles but the researchers demonstrated an unexpected use for the two natural polymers when mixed with stem cells. The team treated blends of silk and cellulose for use as a tiny scaffold that allows adult connective tissue stem cells to form into preliminary form of chondrocytes -- the cells that make healthy tissue cartilage -- and secrete extracellular matrix similar to natural cartilage.
$ G( i& @$ e7 ]. @2 V# [Dr Wael Kafienah, lead author from the University's School of Cellular and Molecular Medicine, said: "We were surprised with this finding, the blend seems to provide complex chemical and mechanical cues that induce stem cell differentiation into preliminary form of chondrocytes without need for biochemical induction using expensive soluble differentiation factors. This new blend can cut the cost for health providers and makes progress towards effective cell-based therapy for cartilage repair a step closer."
. G7 I# C+ L* A. ~* Z+ JDr Sameer Rahatekar, lead author from the University's Advanced Composite Centre for Innovation and Science (ACCIS), added: "We used ionic liquids for the first time to produce cellulose and silk scaffolds for stem cells differentiation. These liquids are effective in dissolving biopolymers and are environmentally benign compared to traditional solvents used for processing of cellulose and silk."
0 x) x1 S, h5 U6 E% h6 N1 _9 lThe teams are currently working on the fabrication of 3D structures from the blend suitable for implantation in patient joints with future studies focusing on understanding the peculiar interactions between the blend and stem cells towards refining the quality of regenerated cartilage.$ P9 b3 }3 ?! p" p& [4 ~# d* q

lizzy_81

这个有相关研究的论文吗

naturalkillerce

回复 lizzy_81 的帖子! E! [4 [. ~# Z2 t2 e( H2 ?
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Directing Chondrogenesis of Stem Cells with Specific Blends of Cellulose and Silk, Biomacromolecules, DOI:10.1021/bm301762p/ D8 S% W. k$ q0 _
http://pubs.acs.org/doi/abs/10.1021/bm301762p

lizzy_81

这个文章我找到了，可是下载不到。

coolyyp

不错
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细胞海洋

ACS子刊:丝绸和纤维素混合物有效促进干细胞修复软骨（附原文）7 ~1 O4 a% `& E+ V, T
http://www.stemcell8.cn/thread-67884-1-1.html
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