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Volume 25, Issue 3On the cover: + _1 G* F1 G8 l# b B
Epidermal growth factor (EGF) induces fast and efficient mitotic progression, ( e# V# }! K- L! _& T9 ~
particularly in cancer cells, by accelerating centrosome separation. Thus, a
6 k `4 p0 n6 {& t/ THeLa cell treated with EGF proceeds faster through mitosis (left path) than a
4 E& |3 Q6 x5 k. } P x/ p: A) ncell left untreated (right path), as visualized by confocal microscopy. 3 Z7 d- P% @5 K' S
H2B-mCherry (red) marks chromosomes; eGFP-laminA (green) marks the nuclear . ]. i% G/ i* {# \* s. k- C' U8 u
envelope. For more information on the effect of EGF on centrosome separation and
3 j! s% d0 P" O$ Pmitotic progress, and on how this may relate to cancer therapeutic strategies, 0 S+ P( d* _; ], s% I4 y. b" S
see Mardin et al., pp. 229–240.. U) Y, c( O" N! A5 u
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发表于 2013-5-21 22:33
发表于 2013-5-22 10:29
