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Volume 25, Issue 3On the cover: & U- Z3 A5 H/ `2 S5 ~6 L
Epidermal growth factor (EGF) induces fast and efficient mitotic progression, # t3 a/ p( [0 J; S
particularly in cancer cells, by accelerating centrosome separation. Thus, a , W5 c9 S1 N6 x! @. M( a* Y7 A
HeLa cell treated with EGF proceeds faster through mitosis (left path) than a
, Y" v6 f! F6 J, @& gcell left untreated (right path), as visualized by confocal microscopy.
4 B9 x* D# P0 T7 \' TH2B-mCherry (red) marks chromosomes; eGFP-laminA (green) marks the nuclear 6 `+ X; h h3 B( {* j& I# `; I7 n
envelope. For more information on the effect of EGF on centrosome separation and
9 z. A0 Z. d3 P- [! h$ Omitotic progress, and on how this may relate to cancer therapeutic strategies,
m9 O B7 R' H0 e$ M3 t' Nsee Mardin et al., pp. 229–240.! D3 K1 z- p5 J% S9 G
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发表于 2013-5-21 22:33
发表于 2013-5-22 10:29
