2013-5-13 Developmental Cell

nero1981

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Volume 25, Issue 3On the cover:
8 _* @; Z9 ^/ Y0 M* GEpidermal growth factor (EGF) induces fast and efficient mitotic progression, % D. R& i6 a$ ^  a
particularly in cancer cells, by accelerating centrosome separation. Thus, a
! ~& M  W6 [' x, B1 oHeLa cell treated with EGF proceeds faster through mitosis (left path) than a / R5 `; A; k3 [5 s+ W  B% v
cell left untreated (right path), as visualized by confocal microscopy.
0 T  P) |. f7 q# KH2B-mCherry (red) marks chromosomes; eGFP-laminA (green) marks the nuclear : g+ L) [0 b3 i4 P) b; O6 P8 a7 }* p
envelope. For more information on the effect of EGF on centrosome separation and
/ M& [+ l; R+ d# a2 b4 t# `mitotic progress, and on how this may relate to cancer therapeutic strategies,
! b1 \5 Y; @3 l9 I3 ]. F8 j& rsee Mardin et al., pp. 229–240.
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