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( S4 N0 B% h, N3 c& s; BVolume 25, Issue 3On the cover:
4 C5 ?9 L9 o. W: E8 b: C' p9 B2 UEpidermal growth factor (EGF) induces fast and efficient mitotic progression, 4 e+ i5 A" e2 K& K
particularly in cancer cells, by accelerating centrosome separation. Thus, a
l' x; y1 _1 j! LHeLa cell treated with EGF proceeds faster through mitosis (left path) than a ; W+ K6 e- J- I l$ v) l# m
cell left untreated (right path), as visualized by confocal microscopy.
6 F: w) I* \8 a/ G+ a D/ ^H2B-mCherry (red) marks chromosomes; eGFP-laminA (green) marks the nuclear
( y# B' z1 k# k$ V* D' |# _$ Cenvelope. For more information on the effect of EGF on centrosome separation and
i2 Z% k4 p2 a5 i3 }mitotic progress, and on how this may relate to cancer therapeutic strategies,
. c" {7 ?% Y6 m+ Rsee Mardin et al., pp. 229–240.
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$ Q5 P) ^6 ^6 p% q5 ?# ^0 M& i& z8 ] |
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发表于 2013-5-21 22:33
