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Volume 25, Issue 3On the cover:
! r8 U# m D+ z) k1 N, R$ EEpidermal growth factor (EGF) induces fast and efficient mitotic progression,
# t# D1 v' H5 iparticularly in cancer cells, by accelerating centrosome separation. Thus, a 1 B q8 R w7 O
HeLa cell treated with EGF proceeds faster through mitosis (left path) than a ( q1 I. ^* j. Q! }# {
cell left untreated (right path), as visualized by confocal microscopy. 3 i0 f- I, d4 k, i; v
H2B-mCherry (red) marks chromosomes; eGFP-laminA (green) marks the nuclear
& r1 [7 k4 \6 r$ [& V8 V, B, S8 menvelope. For more information on the effect of EGF on centrosome separation and 4 Z: w5 e# A% }! B* ~+ N% V+ D
mitotic progress, and on how this may relate to cancer therapeutic strategies, ' Y M3 F5 E( Y/ d( x2 A: B' x
see Mardin et al., pp. 229–240.5 N1 T0 B" q3 {( o3 J# [
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发表于 2013-5-21 22:33
发表于 2013-5-22 10:29
