BioRes Open Access：内耳干细胞有望用于恢复听力

坤明

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2014年6月22日讯 /生物谷BIOON/--螺旋神经节细胞对听觉至关重要，其在内耳的不可逆变性常见于大多数类型的听力损失中。% `7 a+ s' [" G/ T. C

9 Y/ C% N( r! v! Z成年螺旋神经节细胞不能再生，然而，在小鼠模型中新的证据表明，存在于内耳的螺旋神经干细胞能够自我更新，并能生长和诱导分化成成熟的螺旋神经节细胞以及神经元和神经胶质细胞。1 v8 e# P- X7 {6 n5 |7 C  a

7 ~( @& B2 L! t8 j一项新研究得出这样的结论：螺旋神经节干细胞表现出的自我更新特性，使它们成为再生内耳神经结构疗法所需的替换细胞的潜在来源。这些发现特别有意思，因为研究表明，螺旋神经节干细胞可以在体外增殖，而这些细胞在哺乳动物耳朵中通常不再生。( D# b% G! q+ U- q+ z
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坤明

doi:10.1089/biores.2014.0016: u# Y/ D4 T/ B& x) ]8 I/ k
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Spiral Ganglion Stem Cells Can Be Propagated and Differentiated Into Neurons and Glia
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Marc Diensthuber,et al.
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- V. Y. U, Z, W' n9 TThe spiral ganglion is an essential functional component of the peripheral auditory system. Most types of hearing loss are associated with spiral ganglion cell degeneration which is irreversible due to the inner ear's lack of regenerative capacity. Recent studies revealed the existence of stem cells in the postnatal spiral ganglion, which gives rise to the hope that these cells might be useful for regenerative inner ear therapies. Here, we provide an in-depth analysis of sphere-forming stem cells isolated from the spiral ganglion of postnatal mice. We show that spiral ganglion spheres have characteristics similar to neurospheres isolated from the brain. Importantly, spiral ganglion sphere cells maintain their major stem cell characteristics after repeated propagation, which enables the culture of spheres for an extended period of time. In this work, we also demonstrate that differentiated sphere-derived cell populations not only adopt the immunophenotype of mature spiral ganglion cells but also develop distinct ultrastructural features of neurons and glial cells. Thus, our work provides further evidence that self-renewing spiral ganglion stem cells might serve as a promising source for the regeneration of lost auditory neurons.
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鹏程万里

用某些诱导物应该在哺乳动物体内可以再生吧，期待此项研究的进展。