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本帖最后由 细胞海洋 于 2013-6-14 09:50 编辑
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Y Ruzankina1 and EJ Brown*,1
) C$ j' R' \. R1Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 421 Curie Blvd., Philadelphia,9 c; q+ V8 n/ h) g+ }
PA 19104-6160, USA0 K3 b+ k8 i/ Z" S9 `/ `5 i
Ageing is a complex process characterised by a variety of disorders associated with general organismal decline and an inability to! D( j9 b" Y5 N
maintain tissue homoeostasis. As described in this review, recent studies indicate that ageing may be caused, in part, by the depletion- \( l$ b$ z3 g8 F9 z8 E
of stem and progenitor cells that govern tissue renewal. The potential causes of stem and progenitor cell attrition are numerous;# k1 P* a. X8 H. Q* o) _. _/ t
however, a commonly accepted theory is that these cells are lost as a result of naturally occurring DNA damage and the obligate i8 ?7 y6 E( M) D
checkpoint responses that follow. Failure to launch appropriate responses to DNA damage is strongly associated with cancer
4 |( L: ^& x2 l6 H1 zinitiation and progression. Therefore, it is at this nexus, the response to DNA damage, that an important organismal fate may be% f8 n9 D, v8 f% o
determined: to degrade regenerative potential for the purpose of preventing cancer. According to this viewpoint, ageing may be the- z. k* z2 v- F. C
unfortunate mark of successful cancer suppression in stem cells and other cell types. In this review, we will describe how degeneration; ?0 d" t6 p# F6 V' W3 q3 E
of tissue renewal capacity links ageing and cancer suppression.. }- ]1 d9 j- F: \3 @2 y. x
British Journal of Cancer (2007) 97, 1189–1193. doi:10.1038/sj.bjc.6604029 www.bjcancer.com: `* Q* C/ V6 P' l, N
Published online 9 October 2007
1 H) l9 {9 S" C3 V2 g0 r; D& 2007 Cancer Research UK9 I/ C- O: S, J8 z4 J6 H' \7 t
Keywords: ageing; stem cells; DNA damage; oncogenes& H$ [* ^- g& ?0 e2 {& U
5 z# {* w2 \: R3 S; k$ H附件为pdf全文，回复本贴可以下载，感谢对本版主的支持9 e7 c1 m! w& r# G7 s) w! C) Q' s
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Relationships between stem cell exhaustion, tumour suppression and ageing.pdf
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发表于 2009-3-25 09:19
发表于 2009-4-28 09:17
