[全文]丁盛Nat Methods新文章－－提高iPS诱导效率200倍

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Nat Methods. 2009 Oct 18.【Epub ahead of print】( d2 Q6 s1 E& D  _* q
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A chemical platform for improved induction of human iPSCs.
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Lin T, Ambasudhan R, Yuan X, Li W, Hilcove S, Abujarour R, Lin X, Hahm HS, Hao E, Hayek A, Ding S.. N6 D) z& B4 e$ k2 A8 j. B
Department of Chemistry, The Scripps Research Institute, La Jolla, California, USA.
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( n2 I$ U5 }- Q: f) ZThe slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, nonviral methods for reprogramming human somatic cells.3 |  `/ U+ c/ n9 c, w

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