  
- 积分
- 536
- 威望
- 536
- 包包
- 1170
|
Nat Methods. 2009 Oct 18.【Epub ahead of print】0 U) w8 A3 Z8 ?* w3 H. k
' i$ x. D0 x8 G/ o) n% i/ e6 s
4 [1 \* ^9 y( H, o5 }0 P; l
A chemical platform for improved induction of human iPSCs.
* i6 K! K# e" R+ _( d# k: W% N5 K5 j5 v
Lin T, Ambasudhan R, Yuan X, Li W, Hilcove S, Abujarour R, Lin X, Hahm HS, Hao E, Hayek A, Ding S.
4 N5 J* R- x4 D: ]Department of Chemistry, The Scripps Research Institute, La Jolla, California, USA.
8 X% i7 t+ C7 p. T0 U" \# Q- S: W4 y$ X R4 h$ q6 w
The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, nonviral methods for reprogramming human somatic cells.
9 {" |1 |; \+ a& T$ T0 ]% `5 {# C- ?
' n" M; X! L T: E& m; [PMID: 1983816 K9 s3 F9 Y( M$ C$ V+ |
) L, d4 i; ^; L. r. ~ |
附件: 你需要登录才可以下载或查看附件。没有帐号?注册
-
总评分: 威望 + 10
包包 + 10
查看全部评分
|