[全文]丁盛Nat Methods新文章－－提高iPS诱导效率200倍

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Nat Methods. 2009 Oct 18.【Epub ahead of print】0 U) w8 A3 Z8 ?* w3 H. k
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A chemical platform for improved induction of human iPSCs.
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Lin T, Ambasudhan R, Yuan X, Li W, Hilcove S, Abujarour R, Lin X, Hahm HS, Hao E, Hayek A, Ding S.
4 N5 J* R- x4 D: ]Department of Chemistry, The Scripps Research Institute, La Jolla, California, USA.
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The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, nonviral methods for reprogramming human somatic cells.
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' n" M; X! L  T: E& m; [PMID: 1983816  K9 s3 F9 Y( M$ C$ V+ |

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