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Nat Methods. 2009 Oct 18.【Epub ahead of print】2 E7 q+ T% ?' b
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# @8 x: I& V# P! B% j9 FA chemical platform for improved induction of human iPSCs.9 v" P! A% d; M
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Lin T, Ambasudhan R, Yuan X, Li W, Hilcove S, Abujarour R, Lin X, Hahm HS, Hao E, Hayek A, Ding S.
4 V/ N& k( g) O" `Department of Chemistry, The Scripps Research Institute, La Jolla, California, USA.. M; Q" R6 J" O: O- S; p; S
# H3 ~- Z/ x! T4 v5 t- t9 lThe slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (200-fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, nonviral methods for reprogramming human somatic cells.
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PMID: 1983816: w/ `( E! \& s. | i3 \( j+ B
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发表于 2009-10-21 20:20
发表于 2009-10-22 15:52
